Baranger Kévin

Chargé de recherche, HDR

CNRS
Section de Recherche : section 28
Institut référent : INSB

Mots clés : héparanases, métalloprotéases matricielles, inflammation, protéolyse, cible thérapeutique

Responsable de l’axe transversal : Activités secondaires des substances naturelles.

Thèmes de Recherche.
Mon activité de recherche consiste à décrypter les rôles et les relations physiopathologiques du couple héparanase 1 et 2 et des métalloprotéases matricielles (MMPs) dans le cancer du sein, le psoriasis ou la maladie d’Alzheimer. J’étudie en particulier la contribution de ces enzymes dans les processus inflammatoires à l’aide d’approches de biochimie, de biologie cellulaire et moléculaire et de pharmacologie. L’objectif de mes travaux est de valider le ciblage de ces enzymes à l’aide d’oligosaccharides naturels comme nouvelles stratégies thérapeutiques originales.

Publications :

29 résultats

2021

Article dans une revue

A Marine λ-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis
Rémi Cousin , Hugo Groult , Chanez Manseur , Romain Ferru-Clément , Mario Gani , Rachel Havret , Claire Toucheteau , Grégoire Prunier , Béatrice Colin , Franck Morel , Jean-Marie Piot , Isabelle Lanneluc , Kévin Baranger , Thierry Maugard , Ingrid Fruitier-Arnaudin
Marine drugs, MDPI, 2021, 19 (10), pp.546. ⟨10.3390/md19100546⟩

2020

Article dans une revue

Donecopride, a Swiss army knife with potential interest against Alzheimer's disease
Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven , Eleazere Cem , Serge Mignani , Kévin Baranger , Thomas Freret , Joël Bockaert , Santiago Rivera , Michel Boulouard , Patrick Dallemagne , Sylvie Claeysen
British Journal of Pharmacology, Wiley, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩

2019

Article dans une revue

Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP
Laura García-González , Dominika Pilat , Kévin Baranger , Santiago Rivera
Frontiers in Aging Neuroscience, Frontiers, 2019, 11, ⟨10.3389/fnagi.2019.00244⟩
Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders
Santiago Rivera , Laura García-González , Michel Khrestchatisky , Kevin Baranger
Cellular and Molecular Life Sciences, Springer Verlag, 2019, 76 (16), pp.3167-3191. ⟨10.1007/s00018-019-03178-2⟩
Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model
Kévin Baranger , Manuel van Gijsel-Bonnello , Delphine Stephan , Wassila Carpentier , Santiago Rivera , Michel Khrestchatisky , Bouchra Gharib , Max de Reggi , Philippe Benech
Neurotherapeutics, Springer Verlag, 2019, ⟨10.1007/s13311-019-00754-z⟩
Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking
Jean-Michel Paumier , Nathalie Py , Laura García-González , Anne Bernard , Delphine Stephan , Laurence Louis , Frédéric Checler , Michel Khrestchatisky , Kévin Baranger , Santiago Rivera
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (2), pp.2910-2927. ⟨10.1096/fj.201801076R⟩

2018

Article dans une revue

Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer’s Disease
Maria Morello , Véréna Landel , Emmanuelle Lacassagne , Kévin Baranger , Cédric Annweiler , François Féron , Pascal Millet
Molecular Neurobiology, Humana Press, In press, 55 (8), pp.6463-6479. ⟨10.1007/s12035-017-0839-1⟩

2017

Article dans une revue

Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease
Kévin Baranger , Patrizia Giannoni , Stéphane Girard , Sarah Girot , Florence Gaven , Delphine Stephan , Martine Migliorati , Michel Khrestchatisky , Joël Bockaert , Evelyne Marchetti-Gauthier , Santiago Rivera , Sylvie Claeysen , François Roman
Neuropharmacology, Elsevier, 2017, 126, pp.128-141. ⟨10.1016/j.neuropharm.2017.08.031⟩
MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro
Kévin Baranger , Amandine E Bonnet , Stéphane D Girard , Michel Paumier , Laura García-González , Wejdane Elmanaa , Anne Bernard , Eliane Charrat , Delphine Stephan , Charlotte Bauer , Katrin Moschke , Stefan F Lichtenthaler , François S Roman , Frédéric Checler , Michel Khrestchatisky , Santiago Rivera
Frontiers in Molecular Neuroscience, Frontiers Media, 2017, 9, pp.163. ⟨10.3389/fnmol.2016.00163⟩
From Blood to Lesioned Brain: An In Vitro Study on Migration Mechanisms of Human Nasal Olfactory Stem Cells
Stephane Girard , Isabelle Virard , Emmanuelle Lacassagne , Jean-Michel Paumier , Hanae Lahlou , Françoise Jabès , Yves Molino , Delphine Stephan , Kévin Baranger , Maya Belghazi , Arnaud Deveze , Michel Khrestchatisky , Emmanuel Nivet , François Roman , François Feron
Stem Cells International, Hindawi Publishing Corporation, 2017, 2017, 1478606 (17 p.). ⟨10.1155/2017/1478606⟩
Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine
Manuel Gijsel-Bonnello , Kévin Baranger , Philippe Benech , Santiago Rivera , Michel Khrestchatisky , Max Reggi , Bouchra Gharib
PLoS ONE, Public Library of Science, 2017, 12 (4), pp.e0175369. ⟨10.1371/journal.pone.0175369⟩

2016

Article dans une revue

MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?
Kévin Baranger , Michel Khrestchatisky , Santiago Rivera
Journal of Neuroinflammation, BioMed Central, 2016, 13, ⟨10.1186/s12974-016-0633-4⟩
Cerebrovascular pathology during the progression of experimental Alzheimer's disease
Patrizia Giannoni , Margarita Arango-Lievano , Ines das Neves , Marie-Claude Rousset , Kévin Baranger , Santiago Rivera , Freddy Jeanneteau , Sylvie Claeysen , Nicola Marchi
Neurobiology of Disease, Elsevier, 2016, 88, pp.107-117. ⟨10.1016/j.nbd.2016.01.001⟩
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease
Kévin Baranger , Yannick Marchalant , Amandine E. Bonnet , Nadine Crouzin , Alex Carrete , Jean-Michel Paumier , Nathalie A. Py , Anne Bernard , Charlotte Bauer , Eliane Charrat , Katrin Moschke , Mothoharu Seiki , Michel Vignes , Stefan F. Lichtenthaler , Frédéric Checler , Michel Khrestchatisky , Santiago Rivera
Cellular and Molecular Life Sciences, Springer Verlag, 2016, 73 (1), pp.217-236. ⟨10.1007/s00018-015-1992-1⟩

2015

Article dans une revue

Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease
Véréna Landel , Pascal Millet , Kévin Baranger , Béatrice Loriod , François Féron
Molecular Neurodegeneration, BioMed Central, 2015, 11 (1), pp.22. ⟨10.1186/s13024-016-0087-2⟩

2014

Article dans une revue

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease
Stéphane D. Girard , Marlyse Jacquet , Kévin Baranger , Martine Migliorati , Guy Escoffier , Anne Bernard , Michel Khrestchatisky , François Féron , Santiago Rivera , François S. Roman , Evelyne Marchetti
Hippocampus, 2014, 24 (7), pp.762--772. ⟨10.1002/hipo.22267⟩
Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP
Nathalie A. Py , Amandine E. Bonnet , Anne Bernard , Yannick Marchalant , Eliane Charrat , Frédéric Checler , Michel Khrestchatisky , Kévin Baranger , Santiago Rivera
Frontiers in Aging Neuroscience, Frontiers, 2014, 6, pp.247. ⟨10.3389/fnagi.2014.00247⟩
Endogenous and synthetic MMP inhibitors in CNS physiopathology
Kévin Baranger , Santiago Rivera , Fabian D. Liechti , Denis Grandgirard , Judit Bigas , Jesús Seco , Teresa Tarrago , Stephen L. Leib , Michel Khrestchatisky
Progress in Brain Research, 2014, 214, pp.313--351. ⟨10.1016/B978-0-444-63486-3.00014-1⟩

Communication dans un congrès

Memory deficits of 5xFAD mice in the olfactory H maze test correlate with plaques development and are prevented by 5-HT4R agonist treatments.
Patrizia Giannoni , Kévin Baranger , Sarah Girot , Stéphane Girard , Florence Gaven , M Jacquet , Martine Migliorati , Evelyne Marchetti-Gauthier , Santiago Rivera , Sylvie Claeysen , François S. Roman
AAIC, Jul 2014, Copenhague, Denmark
Activation chronique du récepteur de la sérotonine de type 4 : Effet préventif dans un model murin de la maladied’Alzheimer. (Conférencière invitée)
Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , Joël Bockaert , Sylvie Claeysen
Réunion francophone sur la maladie d'Alzheimer, Jun 2014, Montpellier, France

2013

Article dans une revue

Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus
Nadine Crouzin , Kevin Baranger , Mélanie Cavalier , Yannick Marchalant , Catherine Cohen-Solal , François S Roman , Michel Khrestchatisky , Santiago Rivera , François Féron , Michel Vignes
PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e74667. ⟨10.1371/journal.pone.0074667⟩
Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer's disease
Stéphane D. Girard , Kévin Baranger , Cyrielle Gauthier , Marlyse Jacquet , Anne Bernard , Guy Escoffier , Evelyne Marchetti , Michel Khrestchatisky , Santiago Rivera , François S. Roman
Journal of Alzheimer's disease: JAD, 2013, 33 (3), pp.781--796. ⟨10.3233/JAD-2012-120982⟩
Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease
Patrizia Giannoni , Florence Gaven , Dimitri de Bundel , Kévin Baranger , Evelyne Marchetti-Gauthier , François Roman , Emmanuel Valjent , Philippe Marin , Joël Bockaert , Santiago Rivera , Sylvie Claeysen
Frontiers in Aging Neuroscience, Frontiers, 2013, 5, pp.96. ⟨10.3389/fnagi.2013.00096⟩
Role of Matrix Metalloproteinases in Migration and Neurotrophic Properties of Nasal Olfactory Stem and Ensheathing Cells
Adlane Ould-Yahoui , Oualid Sbai , Kevin Baranger , Anne Bernard , Yatma Gueye , Eliane Charrat , Benoit Clement , Didier Gigmes , Vincent Dive , Stephane D. Girard , Francois Féron , Michel Khrestchatisky , Santiago Rivera
Cell Transplantation, Cognizant Communication Corporation, 2013, 22 (6), pp.993--1010. ⟨10.3727/096368912X657468⟩

Communication dans un congrès

5-HT4 agonists: novel promising agents for AD prevention. (Conférencière invitée)
Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , Joël Bockaert , Sylvie Claeysen
36 th meeting of Societa’ Italiana di Farmacologia, 2013, Turin (Italie), October 23, Oct 2013, Turin, Italy
New insights in molecular aspects of Alzheimer’s disease. Conférencière invitée.
Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , Joël Bockaert , Sylvie Claeysen
Sindem, Mar 2013, Perugia, Italy

2012

Article dans une revue

Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?
Yannick Marchalant , Kevin Baranger , Gary L. Wenk , Michel Khrestchatisky , Santiago Rivera
Journal of Neuroinflammation, BioMed Central, 2012, 9, pp.10. ⟨10.1186/1742-2094-9-10⟩

Communication dans un congrès

Prodromal stimulation of 5-HT4 receptors reduces amyloid pathology in 5XFAD mice.
Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , Joël Bockaert , Sylvie Claeysen
Club de neuroprotection, Nov 2012, Paris, France

2011

Article dans une revue

Secretory Leukocyte Protease Inhibitor (SLPI) Is, like Its Homologue Trappin-2 (Pre-Elafin), a Transglutaminase Substrate
Kevin Baranger , Marie-Louise Zani , Valérie Labas , Sandrine Dallet-Choisy , Thierry Moreau
PLoS ONE, Public Library of Science, 2011, 6 (6), ⟨10.1371/journal.pone.0020976⟩