Picot Laurent, MCF-HDR
- Équipe de rattachement : BCBS
- Statut : Chercheur
- laurent.picot@univ-lr.fr
- Tél. : +33 (0)5 46 45 82 20
Enseignant-chercheur, Maître de Conférences
Université de La Rochelle
Section de Recherche : CNU 64
Institut scientifique du CNRS référent : INEE
Mots clés : Anticancéreux, microalgues marines, pigments, hétérocycles, pharmacologie
- Animateur des thématiques de recherche "Pigments marins et Photothérapie dynamique des tumeurs" et "Composition et activité pharmacologique de plantes terrestres Brésiliennes"
- Responsable pour l’université de La Rochelle du Projet Européen Interreg Enhance Microalgae
- Editeur invité numéro spécial "Antiproliferative Marine Natural products" de la revue "Marine Drugs"
Thèmes de Recherche.
- Recherche d’anticancéreux dans l’environnement marin, pharmacologie des anticancéreux
- Extraction, purification, caractérisation moléculaire, activité pharmacologique de pigments de microalgues marines et de plantes terrestres
- Valorisation biotechnologique des ressources marines et botaniques en cancérologie
- Anticancéreux hétérocycliques
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Liste des publications :
35 résultats
2019
Article dans une revue
From ecological relevance of the ecosystem services concept to its socio-political use. The case study of intertidal bare mudflats in the Marennes-Oléron Bay, France
Benoit Lebreton
,
Audrey Rivaud
,
Laurent Picot
,
Benoît Prévost
,
Laurent Barillé
,
Thierry Sauzeau
,
Jennifer Beseres Pollack
,
Johann Lavaud
Ocean & Coastal Management, 2019, 172, pp.41-54. ⟨10.1016/j.ocecoaman.2019.01.024⟩
An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity
Ewa Skała
,
Laurent Picot
,
Michał Bijak
,
Joanna Bijak
,
Janusz Szemraj
,
Agnieszka Kicel
,
Monika Olszewska
,
Przemysław Sitarek
Industrial Crops and Products, Elsevier, 2019, 129, pp.327-338
Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review
Priscila Santos
,
João Pedro S.C.F. Matos
,
Laurent Picot
,
Jackson R.G.S. Almeida
,
Jullyana S.S. Quintans
,
Lucindo J. Quintans-Junior
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.459-469. ⟨10.1016/j.fct.2018.11.030⟩
Monoterpenes modulating cytokines - A review
Jullyana S.S. Quintans
,
Saravanan Shanmugam
,
Luana Heimfarth
,
Adriano Antunes S. Araújo
,
Jackson R.G.da S. Almeida
,
Laurent Picot
,
Lucindo Quintans-Júnior
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.233-257
Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity
Raimundo Gonçalves de Oliveira Júnior
,
Antoine Bonnet
,
Estelle Braconnier
,
Hugo Groult
,
Grégoire Prunier
,
Laureen Beaugeard
,
Raphäel Grougnet
,
Jackson Roberto Guedes da Silva Almeida
,
Christiane Adrielly Alves Ferraz
,
Laurent Picot
Food and Chemical Toxicology, Elsevier, 2019, 125, pp.549-561. ⟨10.1016/j.fct.2019.02.013⟩
2018
Article dans une revue
Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity
Przemysław Sitarek
,
Tomasz Kowalczyk
,
Laurent Picot
,
Dorota Michalska-Hejduk
,
Michał Bijak
,
Adam Białas
,
Marzena Wielanek
,
Tomasz Śliwiński
,
Ewa Skała
Industrial Crops and Products, Elsevier, 2018, 122, pp.732 - 739. ⟨10.1016/j.indcrop.2018.06.059⟩
Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome
Raimundo Gonçalves de Oliveira-Júnior
,
Christiane Alvez Ferraz
,
Michelle Pontes
,
Noelly Bastos Cavalcante
,
Edigênia Cavalcante da Cruz Araújoa
,
Ana Paula de Oliveira
,
Laurent Picot
,
Larissa Rolim
,
Jackson Guedes da Silva Almeida
European Journal of Integrative Medicine, In press
EnhanceMicroalgae: An European Interregional Project Stimulating Research, Innovation, Industrial Development and Transnational Cooperation within the Atlantic Area Microalgae Sector
Judith Rumin
,
Joana Martins
,
Jose Cruz
,
Vitor Vasconcelos
,
Claudio Fuentes Grünewald
,
Kevin J. Flynn
,
Alejandra Sabin
,
Maria Paredes
,
Enma Conde
,
Jose Vilarino
,
Martina Ferreira
,
Federica Farabegoli
,
Paula Fajardo
,
Maria-José Chapela
,
Laurent Picot
Journal of Oceanography and Marine Research, 2018, 6 (3), pp.1000182. ⟨10.4172/2572-3103.1000182⟩
From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines
Frédéric Lassagne
,
Timothy Langlais
,
Elsa Caytan
,
Emmanuelle Limanton
,
Ludovic Paquin
,
Manon Boullard
,
Coline Courtel
,
Idriss Curbet
,
Clément Gédéon
,
Julien Lebreton
,
Laurent Picot
,
Valérie Thiéry
,
Mohamed Souab
,
Blandine Baratte
,
Sandrine Ruchaud
,
Stéphane Bach
,
Thierry Roisnel
,
Florence Mongin
Molecules, MDPI, 2018, 23 (11), pp.2961. ⟨10.3390/molecules23112961⟩
2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities
Nahida Mokhtari Brikci-Nigassa
,
Ghenia Bentabed-Ababsa
,
William Erb
,
Floris Chevallier
,
Laurent Picot
,
Lucille Vitek
,
Audrey Fleury
,
Valérie Thiéry
,
Mohamed Souab
,
Thomas Robert
,
Sandrine Ruchaud
,
Stéphane Bach
,
Thierry Roisnel
,
Florence Mongin
Tetrahedron, Elsevier, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩
Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms
Raimundo Gonçalves de Oliveira Júnior
,
Christiane Adrielly Alves Ferraz
,
Jackson Roberto Guedes da Silva Almeida
,
Raphäel Grougnet
,
Valérie Thiéry
,
Laurent Picot
Fitoterapia, Elsevier, In press, ⟨10.1016/j.fitote.2018.02.025⟩
Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib
Camille Juin
,
Raimundo Gonçalves de Oliveira Junior
,
Audrey Fleury
,
Chloé Oudinet
,
Lior Pytowski
,
Jean-Baptiste Bérard
,
Elodie Nicolau
,
Valérie Thiéry
,
Isabelle Lanneluc
,
Laureen Beaugeard
,
Grégoire Prunier
,
Jackson Roberto Guedes da Silva Almeida
,
Laurent Picot
Revista Brasileira de Farmacognosia, Elsevier, 2018, 28 (4), pp.457-467. ⟨10.1016/j.bjp.2018.05.009⟩
Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.
Alexandra Carvalho
,
Luana Heimfarth
,
Klécia Anjos
,
Adriana Gibara
,
Laurent Picot
,
Jackson Roberto Guedes da Silva Almeida
,
Jullyana de Souza Siqueira Quintans
,
Lucindo José Quintans Junior
Phytomedicine, Elsevier, In press, ⟨10.1016/j.phymed.2018.10.028⟩
2017
Article dans une revue
Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review
Raimundo Gonçalves Oliveira
,
Christiane Adrielly Alves Ferraz
,
Ana Paula Oliveira
,
Camila Souza Araújo
,
Layanne Feitosa da Silva Oliveira
,
Laurent Picot
,
Larissa Araújo Rolim
,
Pedro José Rolim-Neto
,
Jackson Roberto Guedes da Silva Almeida
Phytomedicine, Elsevier, 2017, ⟨10.1016/j.phymed.2017.08.017⟩
Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups
Benoît Serive
,
Elodie Nicolau
,
Jean-Baptiste Bérard
,
Raymond Kaas
,
Virginie Pasquet
,
Laurent Picot
,
Jean-Paul Cadoret
,
Adrianna Ianora
PLoS ONE, Public Library of Science, 2017, 12 (2), ⟨10.1371/journal.pone.0171872⟩
Antimelanoma activity of Heterocapsa triquetra pigments
Quentin Haguet
,
Antoine Bonnet
,
Jean-Baptiste Bérard
,
Joelle Goldberg
,
Nicolas Joguet
,
Audrey Fleury
,
Valérie Thiéry
,
Laurent Picot
Algal Research - Biomass, Biofuels and Bioproducts, Elsevier, 2017, 25, pp.207 - 215. ⟨10.1016/j.algal.2017.04.034⟩
Chapitre d'ouvrage
Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN
Raimundo Gonçalves de Oliveira Junior
,
Christiane Adrielly Alves Ferraz
,
Mariana Gama E Silva
,
Erica Martins de Lavor
,
Larissa Araújo Rolim
,
Julianeli Tolentino de Lima
,
Audrey Fleury
,
Laurent Picot
,
Jullyana de Souza Siqueira Quintans
,
Lucindo José Quintans Junior
,
Jackson Roberto Guedes da Silva Almeida
Natural Products and Cancer Drug Discovery , 2017
Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review
Renan Brito Guedes
,
P. Laise Santos
,
M. Almeida Oliveira
,
Lícia Tairiny Santos Pina
,
Angelo Roberto Antoniolli
,
Jackson Roberto Guedes da Silva Almeida
,
Gokhan Zengin
,
Laurent Picot
,
Jullyana de Souza Siqueira Quintans
,
Lucindo José Quintans Junior
Fibromyalgia and Peripheral Neuropathy , 2017
2016
Article dans une revue
Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?
Raimundo Gonçalves Oliveira-Junior
,
Valérie Thiéry
,
Odile Sergent
,
Martine Chevanne
,
Laurent Picot
Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. ⟨10.4172/jomr.1000144 ⟩
2015
Article dans une revue
Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines
Nada Marquise
,
Tan Tai Nguyen
,
Floris Chevallier
,
Laurent Picot
,
Valérie Thiéry
,
Olivier Lozach
,
Stéphane Bach
,
Sandrine Ruchaud
,
Florence Mongin
SYNLETT, Georg Thieme Verlag, 2015, 26, pp.2811-2816. ⟨10.1055/s-0035-1560496⟩
Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship
Mohamed Yacine Ameur Messaoud
,
Ghenia Bentabed-Ababsa
,
Madani Hedidi
,
Aïcha Derdour
,
Floris Chevallier
,
Yury S. Halauko
,
Oleg A. Ivashkevich
,
Vadim E. Matulis
,
Laurent Picot
,
Valérie Thiéry
,
Thierry Roisnel
,
Vincent Dorcet
,
Florence Mongin
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.1475-1485. ⟨10.3762/bjoc.11.160⟩
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin
,
Antoine Bonnet
,
Elodie Nicolau
,
Jean-Baptiste Bérard
,
Devillers, Romain
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.2541-2558. ⟨10.3390/md13042541⟩
Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.
Camille Juin
,
Jean-René Chérouvrier
,
Valérie Thiery
,
Anne-Laure Gagez
,
Jean-Baptiste Bérard
,
Nicolas, Joguet
,
Raymond Kaas
,
Jean-Paul Cadoret
,
Laurent Picot
Biotechnology and Applied Biochemistry, Wiley, 2015, ⟨10.1007/s12010-014-1250-2⟩
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin
,
Antoine Bonnet
,
Elodie Nicolau
,
Jean-Baptiste Bérard
,
Devillers, Romain
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.1541-2558. ⟨10.3390/md13042541⟩
2014
Article dans une revue
Lutter contre les cancers grâce aux pigments de microalgues
Laurent Picot
Biofutur, Elsevier - Cachan : Lavoisier, 2014
Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells
Madani Hedidi
,
Ghenia Bentabed-Ababsa
,
Aicha Derdour
,
Thierry Roisnel
,
Vincent Dorcet
,
Floris Chevallier
,
Laurent Picot
,
Valérie Thiery
,
Mongin Florence
Bioorganic and Medicinal Chemistry, Elsevier, 2014, pp.1. ⟨10.1016/j.bmc.2014.04.028⟩
2013
Article dans une revue
Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation
Nada Marquise
,
Philip Harford
,
Floris Chevallier
,
Thierry Roisnel
,
Vincent Dorcet
,
Anne-Laure Gagez
,
Sophie Sablé
,
Laurent Picot
,
Valérie Thiéry
,
Andrew Wheatley
,
Philippe Gros
,
Florence Mongin
Tetrahedron, Elsevier, 2013, 69 (47), pp.10123-10133. ⟨10.1016/j.tet.2013.09.030⟩
Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
Paul-Hubert Baudelet
,
Anne-Laure Gagez
,
Jean-Baptiste Bérard
,
Camille Juin
,
Nicolas Bridiau
,
Raymond Kaas
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406
Towards the Clinical Use of Phytoplankton Carotenoid Pigments to Cure Cancer
Camille Juin
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
oceanography, open access, 2013, 1 (3), ⟨10.4172/2332-2632.1000e105⟩
2012
Article dans une revue
The potential of microalgae for the production of bioactive molecules of pharmaceutical interest.
Virginie Mimouni
,
Lionel Ulmann
,
Virginie Pasquet
,
Marie Mathieu
,
Laurent Picot
,
Gaël Bougaran
,
Jean-Paul Cadoret
,
Annick Morant-Manceau
,
Benoît Schoefs
2012, 13 (15), pp.2733-2750
2011
Article dans une revue
Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts
Virginie Pasquet
,
Perrine Morisset
,
Saïd Ihammouine
,
Amandine Chepied
,
Lucie Aumailley
,
Jean-Baptiste Bérard
,
Benoît Serive
,
Raymond Kaas
,
Isabelle Lanneluc
,
Valérie Thiéry
,
Mathieu Lafferière
,
Jean-Marie Piot
,
Thierry Patrice
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2011, 9, pp.819-831. ⟨10.3390/md9050819⟩
2010
Article dans une revue
Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties
Laurent Picot
,
Rozenn Ravallec
,
Martine Fouchereau-Peron
,
Laurent Vandanjon
,
Pascal Jaouen
,
Maryse Chaplain-Derouiniot
,
Fabienne Guérard
,
Aurelie Chabeaud
,
Yves Legal
,
Oscar Martinez Alvarez
,
Jean-Pascal Bergé
,
Jean-Marie Piot
,
Irineu Batista
,
Carla Pires
,
Gudjon Thorkelsson
,
Charles Delannoy
,
Greta Jakobsen
,
Inez Johansson
,
Patrick Bourseau
Journal of the Science of Food and Agriculture, Wiley, 2010, 90 (11), pp.1819-1826. ⟨10.1002/jsfa.4020⟩
2009
Article dans une revue
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives
Anne Beauchard
,
Alexis Jaunet
,
Laurence Murillo
,
Brigitte Baldeyrou
,
Amélie Lansiaux
,
Jean-René Chérouvrier
,
Lisianne Domon
,
Laurent Picot
,
Christian Bailly
,
Thierry Besson
European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (10), pp.3858-3865. ⟨10.1016/j.ejmech.2009.04.012⟩
2008
Article dans une revue
Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III
Alexandra Testard
,
Laurent Picot
,
Ingrid Fruitier-Arnaudin
,
Jean-Marie Piot
,
Hadjila Chabane
,
Lisianne Domon
,
Valérie Thiery
,
Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2008, 19 (6), pp.467-473. ⟨10.1080/14756360412331280491⟩
2005
Article dans une revue
Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.
Alexandra Testard
,
Laurent Picot
,
Olivier Lozach
,
Melina Blairvacq
,
Laurent Meijer
,
Laurence Murillo
,
Jean-Marie Piot
,
Valérie Thiéry
,
Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩