LIttoral ENvironnement et Sociétés (LIENSs) - UMR 7266

Picot Laurent, MCF-HDR

Équipe de rattachement : BCBS
Statut : Chercheur
laurent.picot@univ-lr.fr
Tél. : +33 (0)5 46 45 82 20

Enseignant-chercheur, Maître de Conférences
Université de La Rochelle
Section de Recherche : CNU 64
Institut scientifique du CNRS référent : INEE

Mots clés : Anticancéreux, microalgues marines, pigments, hétérocycles, pharmacologie

Animateur des thématiques de recherche "Pigments marins et Photothérapie dynamique des tumeurs" et "Composition et activité pharmacologique de plantes terrestres Brésiliennes"

Responsable pour l’université de La Rochelle du Projet Européen Interreg Enhance Microalgae

Editeur invité numéro spécial "Antiproliferative Marine Natural products" de la revue "Marine Drugs"

Thèmes de Recherche.

Recherche d’anticancéreux dans l’environnement marin, pharmacologie des anticancéreux
Extraction, purification, caractérisation moléculaire, activité pharmacologique de pigments de microalgues marines et de plantes terrestres
Valorisation biotechnologique des ressources marines et botaniques en cancérologie
Anticancéreux hétérocycliques

Liste des publications :

45 résultats

2020

Article dans une revue

Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest

Blandine Baratte , Nahida Mokhtari Brikci-Nigassa , Lionel Nauton , Pascale Moreau , Olivier Mongin , Raphael Duval , Laurent Picot , Valérie Thiery , Mohamed Souab , Sandrine Ruchaud , Stéphane Bach , Rémy Le Guével , Ghenia Bentabed-Ababsa , William Erb , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Bioorganic Chemistry, Elsevier, 2020, 94, pp.103347. ⟨10.1016/j.bioorg.2019.103347⟩

2019

Article dans une revue

Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review

Christiane Adrielly Alves Ferraz , Raimundo Gonçalves de Oliveira Júnior , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Xirley Pereira Nunes

Fitoterapia, Elsevier, 2019, 137, pp.104196. ⟨10.1016/j.fitote.2019.104196⟩

From ecological relevance of the ecosystem services concept to its socio-political use. The case study of intertidal bare mudflats in the Marennes-Oléron Bay, France

Benoit Lebreton , Audrey Rivaud , Laurent Picot , Benoît Prévost , Laurent Barillé , Thierry Sauzeau , Jennifer Beseres Pollack , Johann Lavaud

Ocean and Coastal Management, Elsevier, 2019, 172, pp.41-54. ⟨10.1016/j.ocecoaman.2019.01.024⟩

An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity

Ewa Skała , Laurent Picot , Michał Bijak , Joanna Bijak , Janusz Szemraj , Agnieszka Kicel , Monika Olszewska , Przemysław Sitarek

Industrial Crops and Products, Elsevier, 2019, 129, pp.327-338

Crystal Structure of 6,7-Dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-dione

Jean Guillon , Maria de Fatima Pereira-Rosenfeld , Noël Pinaud , Thierry Besson , Valérie Thiéry , Laurent Picot , Mathieu Marchivie

X-Ray Structure Analysis Online, Japan Society for Analytical Chemistry's, 2019, 35 (10), pp.57-59. ⟨10.2116/xraystruct.35.57⟩

Chemical constituents of non-polar fractions obtained from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant native to Caatinga biome Chemical constituents of non-polar fractions obtained from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant native to Caatinga biome

Raimundo G. de Oliveira-Júnior , Christiane Adrielly A. Ferraz , Ana Paula de Oliveira , José Marcos T. de Alencar-Filho , Edigênia C. C. Araújo , Xirley P. Nunes , Laurent Picot , Norberto Lopes , Raimundo Braz-Filho , Larissa A. Rolim , Jackson Roberto G. da S. Almeida

Revista Virtual de Química, 2019, 11 (2), pp.498-516. ⟨10.21577/1984-6835.20190038⟩

Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review

Priscila Santos , João Pedro S.C.F. Matos , Laurent Picot , Jackson R.G.S. Almeida , Jullyana S.S. Quintans , Lucindo J. Quintans-Junior

Food and Chemical Toxicology, Elsevier, 2019, 123, pp.459-469. ⟨10.1016/j.fct.2018.11.030⟩

Monoterpenes modulating cytokines - A review

Jullyana S.S. Quintans , Saravanan Shanmugam , Luana Heimfarth , Adriano Antunes S. Araújo , Jackson R.G.da S. Almeida , Laurent Picot , Lucindo Quintans-Júnior

Food and Chemical Toxicology, Elsevier, 2019, 123, pp.233-257

Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity

Raimundo Gonçalves de Oliveira Júnior , Antoine Bonnet , Estelle Braconnier , Hugo Groult , Grégoire Prunier , Laureen Beaugeard , Raphäel Grougnet , Jackson Roberto Guedes da Silva Almeida , Christiane Adrielly Alves Ferraz , Laurent Picot

Food and Chemical Toxicology, Elsevier, 2019, 125, pp.549-561. ⟨10.1016/j.fct.2019.02.013⟩

2018

Article dans une revue

Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity

Przemysław Sitarek , Tomasz Kowalczyk , Laurent Picot , Dorota Michalska-Hejduk , Michał Bijak , Adam Białas , Marzena Wielanek , Tomasz Śliwiński , Ewa Skała

Industrial Crops and Products, Elsevier, 2018, 122, pp.732 - 739. ⟨10.1016/j.indcrop.2018.06.059⟩

Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.

Alexandra Carvalho , Luana Heimfarth , Klécia Anjos , Adriana Gibara , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior

Phytomedicine, Elsevier, In press, ⟨10.1016/j.phymed.2018.10.028⟩

EnhanceMicroalgae: An European Interregional Project Stimulating Research, Innovation, Industrial Development and Transnational Cooperation within the Atlantic Area Microalgae Sector

Judith Rumin , Joana Martins , Jose Cruz , Vitor Vasconcelos , Claudio Fuentes Grünewald , Kevin J. Flynn , Alejandra Sabin , Maria Paredes , Enma Conde , Jose Vilarino , Martina Ferreira , Federica Farabegoli , Paula Fajardo , Maria-José Chapela , Laurent Picot

Journal of Oceanography and Marine Research, 2018, 6 (3), pp.1000182. ⟨10.4172/2572-3103.1000182⟩

Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome

Raimundo Gonçalves de Oliveira-Júnior , Christiane Alvez Ferraz , Michelle Pontes , Noelly Bastos Cavalcante , Edigênia Cavalcante da Cruz Araújoa , Ana Paula de Oliveira , Laurent Picot , Larissa Rolim , Jackson Guedes da Silva Almeida

European Journal of Integrative Medicine, In press

Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib

Camille Juin , Raimundo Gonçalves de Oliveira Junior , Audrey Fleury , Chloé Oudinet , Lior Pytowski , Jean-Baptiste Bérard , Elodie Nicolau , Valérie Thiéry , Isabelle Lanneluc , Laureen Beaugeard , Grégoire Prunier , Jackson Roberto Guedes da Silva Almeida , Laurent Picot

Revista Brasileira de Farmacognosia, Elsevier, 2018, 28 (4), pp.457-467. ⟨10.1016/j.bjp.2018.05.009⟩

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin , Manon Boullard , Coline Courtel , Idriss Curbet , Clément Gédéon , Julien Lebreton , Laurent Picot , Valérie Thiéry , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin

Molecules, MDPI, 2018, 23 (11), pp.2961. ⟨10.3390/molecules23112961⟩

2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot , Lucille Vitek , Audrey Fleury , Valérie Thiéry , Mohamed Souab , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin

Tetrahedron, Elsevier, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩

Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms

Raimundo Gonçalves de Oliveira Júnior , Christiane Adrielly Alves Ferraz , Jackson Roberto Guedes da Silva Almeida , Raphäel Grougnet , Valérie Thiéry , Laurent Picot

Fitoterapia, Elsevier, In press, ⟨10.1016/j.fitote.2018.02.025⟩

Communication dans un congrès

Natural compounds targeting pyocyanin and quorum sensing in Pseudomonas aeruginosa

Ali Tahrioui , Onyedikachi Azuama , Sergio Ortiz , Raimundo Gonçalves , Damien Tortuel , Olivier Maillot , Chouaha Bouzidi , Laurent Picot , Raphaël Grougnet , Sabrina Boutefnouchet , Marina Kritsanida , Marc Feuilloley , Nicole Orange , Sylvie Michel , Olivier Lesouhaitier , Emeline Bouffartigues , Sylvie Chevalier

Congrès National de la Société Française de Microbiologie-SFM2018, Oct 2018, Paris, France

2017

Article dans une revue

Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review

Raimundo Gonçalves Oliveira , Christiane Adrielly Alves Ferraz , Ana Paula Oliveira , Camila Souza Araújo , Layanne Feitosa da Silva Oliveira , Laurent Picot , Larissa Araújo Rolim , Pedro José Rolim-Neto , Jackson Roberto Guedes da Silva Almeida

Phytomedicine, Elsevier, 2017, ⟨10.1016/j.phymed.2017.08.017⟩

Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups

Benoît Serive , Elodie Nicolau , Jean-Baptiste Bérard , Raymond Kaas , Virginie Pasquet , Laurent Picot , Jean-Paul Cadoret , Adrianna Ianora

PLoS ONE, Public Library of Science, 2017, 12 (2), ⟨10.1371/journal.pone.0171872⟩

Antimelanoma activity of Heterocapsa triquetra pigments

Quentin Haguet , Antoine Bonnet , Jean-Baptiste Bérard , Joelle Goldberg , Nicolas Joguet , Audrey Fleury , Valérie Thiéry , Laurent Picot

Algal Research - Biomass, Biofuels and Bioproducts, Elsevier, 2017, 25, pp.207 - 215. ⟨10.1016/j.algal.2017.04.034⟩

Chapitre d'ouvrage

Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN

Raimundo Gonçalves de Oliveira Junior , Christiane Adrielly Alves Ferraz , Mariana Gama E Silva , Erica Martins de Lavor , Larissa Araújo Rolim , Julianeli Tolentino de Lima , Audrey Fleury , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior , Jackson Roberto Guedes da Silva Almeida

Natural Products and Cancer Drug Discovery , 2017

Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review

Renan Brito Guedes , P. Laise Santos , M. Almeida Oliveira , Lícia Tairiny Santos Pina , Angelo Roberto Antoniolli , Jackson Roberto Guedes da Silva Almeida , Gokhan Zengin , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior

Fibromyalgia and Peripheral Neuropathy , 2017

2016

Article dans une revue

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

Raimundo Gonçalves Oliveira-Junior , Valérie Thiéry , Odile Sergent , Martine Chevanne , Laurent Picot

Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. ⟨10.4172/jomr.1000144 ⟩

2015

Article dans une revue

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines

Nada Marquise , Tan Tai Nguyen , Floris Chevallier , Laurent Picot , Valérie Thiéry , Olivier Lozach , Stéphane Bach , Sandrine Ruchaud , Florence Mongin

SYNLETT, Georg Thieme Verlag, 2015, 26 (20), pp.2811-2816. ⟨10.1055/s-0035-1560496⟩

Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship

Mohamed Yacine Ameur Messaoud , Ghenia Bentabed-Ababsa , Madani Hedidi , Aïcha Derdour , Floris Chevallier , Yury S. Halauko , Oleg A. Ivashkevich , Vadim E. Matulis , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.1475-1485. ⟨10.3762/bjoc.11.160⟩

UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum

Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

Marine drugs, MDPI, 2015, 13 (4), pp.2541-2558. ⟨10.3390/md13042541⟩

Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.

Camille Juin , Jean-René Chérouvrier , Valérie Thiery , Anne-Laure Gagez , Jean-Baptiste Bérard , Nicolas, Joguet , Raymond Kaas , Jean-Paul Cadoret , Laurent Picot

Biotechnology and Applied Biochemistry, Wiley, 2015, ⟨10.1007/s12010-014-1250-2⟩

UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum

Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

Marine drugs, MDPI, 2015, 13 (4), pp.1541-2558. ⟨10.3390/md13042541⟩

2014

Article dans une revue

Lutter contre les cancers grâce aux pigments de microalgues

Laurent Picot

Biofutur, Elsevier - Cachan : Lavoisier, 2014

Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

Madani Hedidi , Ghenia Bentabed-Ababsa , Aicha Derdour , Thierry Roisnel , Vincent Dorcet , Floris Chevallier , Laurent Picot , Valérie Thiery , Mongin Florence

Bioorganic and Medicinal Chemistry, Elsevier, 2014, pp.1. ⟨10.1016/j.bmc.2014.04.028⟩

2013

Article dans une revue

Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation

Nada Marquise , Philip Harford , Floris Chevallier , Thierry Roisnel , Vincent Dorcet , Anne-Laure Gagez , Sophie Sablé , Laurent Picot , Valérie Thiéry , Andrew Wheatley , Philippe Gros , Florence Mongin

Tetrahedron, Elsevier, 2013, 69 (47), pp.10123-10133. ⟨10.1016/j.tet.2013.09.030⟩

Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

Paul-Hubert Baudelet , Anne-Laure Gagez , Jean-Baptiste Bérard , Camille Juin , Nicolas Bridiau , Raymond Kaas , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406

Towards the Clinical Use of Phytoplankton Carotenoid Pigments to Cure Cancer

Camille Juin , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

oceanography, open access, 2013, 1 (3), ⟨10.4172/2332-2632.1000e105⟩

2012

Article dans une revue

The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest

Virginie Mimouni , Lionel Ulmann , Virginie Pasquet , Marie Mathieu , Laurent Picot , Gaël Bougaran , Jean-Paul Cadoret , Annick Morant-Manceau , Benoît Schoefs

Current Pharmaceutical Biotechnology, Bentham Science Publishers, 2012, 13 (15), pp.2733-2750. ⟨10.2174/138920112804724828⟩

The potential of microalgae for the production of bioactive molecules of pharmaceutical interest.

Virginie Mimouni , Lionel Ulmann , Virginie Pasquet , Marie Mathieu , Laurent Picot , Gaël Bougaran , Jean-Paul Cadoret , Annick Morant-Manceau , Benoît Schoefs

2012, 13 (15), pp.2733-2750

2011

Article dans une revue

Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts

Virginie Pasquet , Perrine Morisset , Saïd Ihammouine , Amandine Chepied , Lucie Aumailley , Jean-Baptiste Bérard , Benoît Serive , Raymond Kaas , Isabelle Lanneluc , Valérie Thiéry , Mathieu Lafferière , Jean-Marie Piot , Thierry Patrice , Jean-Paul Cadoret , Laurent Picot

Marine drugs, MDPI, 2011, 9, pp.819-831. ⟨10.3390/md9050819⟩

2010

Article dans une revue

Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties

Laurent Picot , Rozenn Ravallec , Martine Fouchereau-Peron , Laurent Vandanjon , Pascal Jaouen , Maryse Chaplain-Derouiniot , Fabienne Guérard , Aurelie Chabeaud , Yves Legal , Oscar Martinez Alvarez , Jean-Pascal Bergé , Jean-Marie Piot , Irineu Batista , Carla Pires , Gudjon Thorkelsson , Charles Delannoy , Greta Jakobsen , Inez Johansson , Patrick Bourseau

Journal of the Science of Food and Agriculture, Wiley, 2010, 90 (11), pp.1819-1826. ⟨10.1002/jsfa.4020⟩

2009

Article dans une revue

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives

Anne Beauchard , Alexis Jaunet , Laurence Murillo , Brigitte Baldeyrou , Amélie Lansiaux , Jean-René Chérouvrier , Lisianne Domon , Laurent Picot , Christian Bailly , Thierry Besson

European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (10), pp.3858-3865. ⟨10.1016/j.ejmech.2009.04.012⟩

2008

Article dans une revue

Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III

Alexandra Testard , Laurent Picot , Ingrid Fruitier-Arnaudin , Jean-Marie Piot , Hadjila Chabane , Lisianne Domon , Valérie Thiery , Thierry Besson

Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2008, 19 (6), pp.467-473. ⟨10.1080/14756360412331280491⟩

2007

Article dans une revue

Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

François Liger , Florence Popowycz , Thierry Besson , Laurent Picot , Carlos Galmarini , Benoît Joseph

Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 15 (16), pp.5615-5619. ⟨10.1016/j.bmc.2007.05.033⟩

2005

Article dans une revue

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.

Alexandra Testard , Laurent Picot , Olivier Lozach , Melina Blairvacq , Laurent Meijer , Laurence Murillo , Jean-Marie Piot , Valérie Thiéry , Thierry Besson

Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩

2004

Article dans une revue

Regulation of the cytotoxic effects of Pseudomonas fluorescens by growth temperature

Laurent Picot , Sana Mezghani-Abdelmoula , Sylvie Chevalier , Annabelle Merieau , Olivier Lesouhaitier , Josette Guerillon , Lionel Cazin , Nicole Orange , Marc G.J. Feuilloley

Research in Microbiology, Elsevier, 2004, 155 (1), pp.39-46. ⟨10.1016/j.resmic.2003.09.014⟩

2003

Article dans une revue

Cytotoxic effects of the lipopolysaccharide from Pseudomonas fluorescens on neurons and glial cells

Laurent Picot , Sylvie Chevalier , Sana Mezghani-Abdelmoula , Annabelle Mérieau , Olivier Lesouhaitier , Philippe Leroux , Lionel Cazin , Nicole Orange , Marc G.J Feuilloley

Microbial Pathogenesis, Elsevier, 2003, 35 (3), pp.95-106. ⟨10.1016/s0882-4010(03)00092-5⟩

2001

Article dans une revue

Pseudomonas fluorescens as a potential pathogen: adherence to nerve cells

Laurent Picot , Sana Mezghani Abdelmoula , Annabelle Mérieau , Philippe Leroux , Lionel Cazin , Nicole Orange , Marc G.J Feuilloley

Microbes and Infection, Elsevier, 2001, 3 (12), pp.985-995. ⟨10.1016/s1286-4579(01)01462-9⟩