Picot Laurent, MCF-HDR

Enseignant-chercheur, Maître de Conférences
Université de La Rochelle
Section de Recherche : CNU 64
Institut scientifique du CNRS référent : INEE

Mots clés : Anticancéreux, microalgues marines, pigments, hétérocycles, pharmacologie

  • Animateur des thématiques de recherche "Pigments marins et Photothérapie dynamique des tumeurs" et "Composition et activité pharmacologique de plantes terrestres Brésiliennes"
  • Responsable pour l’université de La Rochelle du Projet Européen Interreg Enhance Microalgae
  • Editeur invité numéro spécial "Antiproliferative Marine Natural products" de la revue "Marine Drugs"
Thèmes de Recherche.
  • Recherche d’anticancéreux dans l’environnement marin, pharmacologie des anticancéreux
  • Extraction, purification, caractérisation moléculaire, activité pharmacologique de pigments de microalgues marines et de plantes terrestres
  • Valorisation biotechnologique des ressources marines et botaniques en cancérologie
  • Anticancéreux hétérocycliques

Liste des publications :

33 résultats

2019

Article dans une revue

An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity
Ewa Skała , Laurent Picot , Michał Bijak , Joanna Bijak , Janusz Szemraj , Agnieszka Kicel , Monika Olszewska , Przemysław Sitarek
Industrial Crops and Products, Elsevier, 2019, 129, pp.327-338
Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review
Priscila Santos , João Pedro S.C.F. Matos , Laurent Picot , Jackson R.G.S. Almeida , Jullyana S.S. Quintans , Lucindo J. Quintans-Junior
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.459-469. 〈10.1016/j.fct.2018.11.030〉
Monoterpenes modulating cytokines - A review
Jullyana S.S. Quintans , Saravanan Shanmugam , Luana Heimfarth , Adriano Antunes S. Araújo , Jackson R.G.Da S. Almeida , Laurent Picot , Lucindo Quintans-Júnior
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.233-257

2018

Article dans une revue

Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity
Przemysław Sitarek , Tomasz Kowalczyk , Laurent Picot , Dorota Michalska-Hejduk , Michał Bijak , Adam Białas , Marzena Wielanek , Tomasz Śliwiński , Ewa Skała
Industrial Crops and Products, Elsevier, 2018, 122, pp.732 - 739. 〈10.1016/j.indcrop.2018.06.059〉
Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome
Raimundo Gonçalves de Oliveira-Júnior , Christiane Alvez Ferraz , Michelle Pontes , Noelly Bastos Cavalcante , Edigênia Cavalcante da Cruz Araújoa , Ana Paula de Oliveira , Laurent Picot , Larissa Rolim , Jackson Guedes da Silva Almeida
European Journal of Integrative Medicine, In press
Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib
Camille Juin , Raimundo Gonçalves de Oliveira Junior , Audrey Fleury , Chloé Oudinet , Lior Pytowski , Jean-Baptiste Bérard , Elodie Nicolau , Valérie Thiéry , Isabelle Lanneluc , Laureen Beaugeard , Grégoire Prunier , Jackson Roberto Guedes da Silva Almeida , Laurent Picot
Revista Brasileira de Farmacognosia, Elsevier, 2018, 28 (4), pp.457-467. 〈10.1016/j.bjp.2018.05.009〉
EnhanceMicroalgae: An European Interregional Project Stimulating Research, Innovation, Industrial Development and Transnational Cooperation within the Atlantic Area Microalgae Sector
Judith Rumin , Joana Martins , Jose Cruz , Vitor Vasconcelos , Claudio Fuentes Grünewald , Kevin J. Flynn , Alejandra Sabin , Maria Paredes , Enma Conde , Jose Vilarino , Martina Ferreira , Federica Farabegoli , Paula Fajardo , Maria-José Chapela , Laurent Picot
Journal of Oceanography and Marine Research, 2018, 6 (3), pp.1000182. 〈10.4172/2572-3103.1000182〉
Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.
Alexandra Carvalho , Luana Heimfarth , Klécia Anjos , Adriana Gibara , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Jullyana De Souza Siqueira Quintans , Lucindo José Quintans Junior
Phytomedicine, Elsevier, In press, 〈10.1016/j.phymed.2018.10.028〉
Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms
Raimundo Gonçalves De Oliveira Júnior , Christiane Adrielly Alves Ferraz , Jackson Roberto Guedes Da Silva Almeida , Raphäel Grougnet , Valérie Thiéry , Laurent Picot
Fitoterapia, Elsevier, In press, 〈10.1016/j.fitote.2018.02.025〉
2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities
Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot , Lucille Vitek , Audrey Fleury , Valérie Thiéry , Mohamed Souab , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin
Tetrahedron, Elsevier, 2018, 74 (15), pp.1785-1801. 〈10.1016/j.tet.2018.02.038〉
From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines
Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin , Manon Boullard , Coline Courtel , Idriss Curbet , Clément Gédéon , Julien Lebreton , Laurent Picot , Valérie Thiéry , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin
Molecules, MDPI, 2018, 23 (11), 〈10.3390/molecules23112961〉

2017

Article dans une revue

Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review
Raimundo Gonçalves Oliveira , Christiane Adrielly Alves Ferraz , Ana Paula Oliveira , Camila Souza Araújo , Layanne Feitosa da Silva Oliveira , Laurent Picot , Larissa Araújo Rolim , Pedro José Rolim-Neto , Jackson Roberto Guedes da Silva Almeida
Phytomedicine, Elsevier, 2017, 〈10.1016/j.phymed.2017.08.017〉
Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups
Benoît Serive , Elodie Nicolau , Jean-Baptiste Bérard , Raymond Kaas , Virginie Pasquet , Laurent Picot , Jean-Paul Cadoret , Adrianna Ianora
PLoS ONE, Public Library of Science, 2017, 12 (2), 〈10.1371/journal.pone.0171872〉
Antimelanoma activity of Heterocapsa triquetra pigments
Quentin Haguet , Antoine Bonnet , Jean-Baptiste Bérard , Joelle Goldberg , Nicolas Joguet , Audrey Fleury , Valérie Thiéry , Laurent Picot
Algal Research - Biomass, Biofuels and Bioproducts, Elsevier, 2017, 25, pp.207 - 215. 〈10.1016/j.algal.2017.04.034〉

Chapitre d'ouvrage

Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review
Renan Brito Guedes , P. Laise Santos , M. Almeida Oliveira , Lícia Tairiny Santos Pina , Angelo Roberto Antoniolli , Jackson Roberto Guedes da Silva Almeida , Gokhan Zengin , Laurent Picot , Jullyana De Souza Siqueira Quintans , Lucindo José Quintans Junior
Fibromyalgia and Peripheral Neuropathy , 2017
Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN
Raimundo Gonçalves de Oliveira Junior , Christiane Adrielly Alves Ferraz , Mariana Gama E Silva , Erica Martins de Lavor , Larissa Araújo Rolim , Julianeli Tolentino de Lima , Audrey Fleury , Laurent Picot , Jullyana De Souza Siqueira Quintans , Lucindo José Quintans Junior , Jackson Roberto Guedes da Silva Almeida
Natural Products and Cancer Drug Discovery , 2017

2016

Article dans une revue

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?
Raimundo Gonçalves Oliveira-Junior , Valérie Thiéry , Odile Sergent , Martine Chevanne , Laurent Picot
Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. 〈10.4172/jomr.1000144 〉

2015

Article dans une revue

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines
Nada Marquise , Tan Tai Nguyen , Floris Chevallier , Laurent Picot , Valérie Thiéry , Olivier Lozach , Stéphane Bach , Sandrine Ruchaud , Florence Mongin
SYNLETT, Georg Thieme Verlag, 2015, 26, pp.2811-2816. 〈10.1055/s-0035-1560496〉
Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship
Mohamed Yacine Ameur Messaoud , Ghenia Bentabed-Ababsa , Madani Hedidi , Aïcha Derdour , Floris Chevallier , Yury S. Halauko , Oleg A. Ivashkevich , Vadim E. Matulis , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.1475-1485. 〈10.3762/bjoc.11.160〉
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.2541-2558. 〈10.3390/md13042541〉
Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.
Camille Juin , Jean-René Chérouvrier , Valérie Thiery , Anne-Laure Gagez , Jean-Baptiste Bérard , Nicolas, Joguet , Raymond Kaas , Jean-Paul Cadoret , Laurent Picot
Biotechnology and Applied Biochemistry, Wiley, 2015, 〈10.1007/s12010-014-1250-2〉
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.1541-2558. 〈10.3390/md13042541〉

2014

Article dans une revue

Lutter contre les cancers grâce aux pigments de microalgues
Laurent Picot
Biofutur, Elsevier - Cachan : Lavoisier, 2014
Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells
Madani Hedidi , Ghenia Bentabed-Ababsa , Aicha Derdour , Thierry Roisnel , Vincent Dorcet , Floris Chevallier , Laurent Picot , Valérie Thiery , Mongin Florence
Bioorg. Med. Chem., 2014, pp.1. 〈10.1016/j.bmc.2014.04.028〉

2013

Article dans une revue

Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation
Nada Marquise , Philip Harford , Floris Chevallier , Thierry Roisnel , Vincent Dorcet , Anne-Laure Gagez , Sophie Sablé , Laurent Picot , Valérie Thiéry , Andrew Wheatley , Philippe Gros , Florence Mongin
Tetrahedron, Elsevier, 2013, 69 (47), pp.10123-10133. 〈10.1016/j.tet.2013.09.030〉
Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
Paul-Hubert Baudelet , Anne-Laure Gagez , Jean-Baptiste Bérard , Camille Juin , Nicolas Bridiau , Raymond Kaas , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406
Towards the Clinical Use of Phytoplankton Carotenoid Pigments to Cure Cancer
Camille Juin , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
oceanography, open access, 2013, 1 (3), 〈10.4172/2332-2632.1000e105〉

2012

Article dans une revue

The potential of microalgae for the production of bioactive molecules of pharmaceutical interest.
Virginie Mimouni , Lionel Ulmann , Virginie Pasquet , Marie Mathieu , Laurent Picot , Gaël Bougaran , Jean-Paul Cadoret , Annick Morant-Manceau , Benoît Schoefs
2012, 13 (15), pp.2733-2750

2011

Article dans une revue

Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts
Virginie Pasquet , Perrine Morisset , Saïd Ihammouine , Amandine Chepied , Lucie Aumailley , Jean-Baptiste Bérard , Benoît Serive , Raymond Kaas , Isabelle Lanneluc , Valérie Thiéry , Mathieu Lafferière , Jean-Marie Piot , Thierry Patrice , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2011, 9, pp.819-831. 〈10.3390/md9050819〉

2010

Article dans une revue

Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties
Laurent Picot , Rozenn Ravallec , Martine Fouchereau-Peron , Laurent Vandanjon , Pascal Jaouen , Maryse Chaplain-Derouiniot , Fabienne Guérard , Aurelie Chabeaud , Yves Legal , Oscar Martinez Alvarez , Jean-Pascal Bergé , Jean-Marie Piot , Irineu Batista , Carla Pires , Gudjon Thorkelsson , Charles Delannoy , Greta Jakobsen , Inez Johansson , Patrick Bourseau
Journal of the Science of Food and Agriculture, Wiley, 2010, 90 (11), pp.1819-1826. 〈10.1002/jsfa.4020〉

2009

Article dans une revue

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives
Anne Beauchard , Alexis Jaunet , Laurence Murillo , Brigitte Baldeyrou , Amélie Lansiaux , Jean-René Chérouvrier , Lisianne Domon , Laurent Picot , Christian Bailly , Thierry Besson
European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (10), pp.3858 - 3865. 〈10.1016/j.ejmech.2009.04.012〉

2008

Article dans une revue

Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III
Alexandra Testard , Laurent Picot , Ingrid Fruitier-Arnaudin , Jean-Marie Piot , Hadjila Chabane , Lisianne Domon , Valérie Thiery , Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2008, 19 (6), pp.467-473

2005

Article dans une revue

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.
Alexandra Testard , Laurent Picot , Olivier Lozach , Melina Blairvacq , Laurent Meijer , Laurence Murillo , Jean-Marie Piot , Valérie Thiéry , Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-68