Picot Laurent, MCF-HDR

Enseignant-chercheur, Maître de Conférences
Université de La Rochelle
Section de Recherche : CNU 64
Institut scientifique du CNRS référent : INEE

Mots clés : Anticancéreux, microalgues marines, pigments, hétérocycles, pharmacologie

  • Animateur des thématiques de recherche "Pigments marins et Photothérapie dynamique des tumeurs" et "Composition et activité pharmacologique de plantes terrestres Brésiliennes"
  • Responsable pour l’université de La Rochelle du Projet Européen Interreg Enhance Microalgae
  • Editeur invité numéro spécial "Antiproliferative Marine Natural products" de la revue "Marine Drugs"
Thèmes de Recherche.
  • Recherche d’anticancéreux dans l’environnement marin, pharmacologie des anticancéreux
  • Extraction, purification, caractérisation moléculaire, activité pharmacologique de pigments de microalgues marines et de plantes terrestres
  • Valorisation biotechnologique des ressources marines et botaniques en cancérologie
  • Anticancéreux hétérocycliques

Liste des publications :

36 résultats

2019

Article dans une revue

From ecological relevance of the ecosystem services concept to its socio-political use. The case study of intertidal bare mudflats in the Marennes-Oléron Bay, France
Benoit Lebreton , Audrey Rivaud , Laurent Picot , Benoit Prévost , Laurent Barillé , Thierry Sauzeau , Jennifer Beseres Pollack , Johann Lavaud
Ocean & Coastal Management, 2019, 172, pp.41-54. ⟨10.1016/j.ocecoaman.2019.01.024⟩
From ecological relevance of the ecosystem services concept to its socio-political use. The case study of intertidal bare mudflats in the Marennes-Oléron Bay, France
Benoit Lebreton , Audrey Rivaud , Laurent Picot , Benoît Prévost , Laurent Barillé , Thierry Sauzeau , Jennifer Beseres Pollack , Johann Lavaud
Ocean & Coastal Management, 2019, 172, pp.41-54. ⟨10.1016/j.ocecoaman.2019.01.024⟩
An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity
Ewa Skała , Laurent Picot , Michał Bijak , Joanna Bijak , Janusz Szemraj , Agnieszka Kicel , Monika Olszewska , Przemysław Sitarek
Industrial Crops and Products, Elsevier, 2019, 129, pp.327-338
Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity
Raimundo Gonçalves de Oliveira Júnior , Antoine Bonnet , Estelle Braconnier , Hugo Groult , Grégoire Prunier , Laureen Beaugeard , Raphäel Grougnet , Jackson Roberto Guedes Da Silva Almeida , Christiane Adrielly Alves Ferraz , Laurent Picot
Food and Chemical Toxicology, Elsevier, 2019, 125, pp.549-561. ⟨10.1016/j.fct.2019.02.013⟩
Monoterpenes modulating cytokines - A review
Jullyana S.S. Quintans , Saravanan Shanmugam , Luana Heimfarth , Adriano Antunes S. Araújo , Jackson R.G.Da S. Almeida , Laurent Picot , Lucindo Quintans-Júnior
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.233-257
Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review
Priscila Santos , João Pedro S.C.F. Matos , Laurent Picot , Jackson R.G.S. Almeida , Jullyana S.S. Quintans , Lucindo J. Quintans-Junior
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.459-469. ⟨10.1016/j.fct.2018.11.030⟩

2018

Article dans une revue

Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity
Przemysław Sitarek , Tomasz Kowalczyk , Laurent Picot , Dorota Michalska-Hejduk , Michał Bijak , Adam Białas , Marzena Wielanek , Tomasz Śliwiński , Ewa Skała
Industrial Crops and Products, Elsevier, 2018, 122, pp.732 - 739. ⟨10.1016/j.indcrop.2018.06.059⟩
Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib
Camille Juin , Raimundo Gonçalves de Oliveira Junior , Audrey Fleury , Chloé Oudinet , Lior Pytowski , Jean-Baptiste Bérard , Elodie Nicolau , Valérie Thiéry , Isabelle Lanneluc , Laureen Beaugeard , Grégoire Prunier , Jackson Roberto Guedes da Silva Almeida , Laurent Picot
Revista Brasileira de Farmacognosia, Elsevier, 2018, 28 (4), pp.457-467. ⟨10.1016/j.bjp.2018.05.009⟩
Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome
Raimundo Gonçalves de Oliveira-Júnior , Christiane Alvez Ferraz , Michelle Pontes , Noelly Bastos Cavalcante , Edigênia Cavalcante da Cruz Araújoa , Ana Paula de Oliveira , Laurent Picot , Larissa Rolim , Jackson Guedes da Silva Almeida
European Journal of Integrative Medicine, In press
EnhanceMicroalgae: An European Interregional Project Stimulating Research, Innovation, Industrial Development and Transnational Cooperation within the Atlantic Area Microalgae Sector
Judith Rumin , Joana Martins , Jose Cruz , Vitor Vasconcelos , Claudio Fuentes Grünewald , Kevin J. Flynn , Alejandra Sabin , Maria Paredes , Enma Conde , Jose Vilarino , Martina Ferreira , Federica Farabegoli , Paula Fajardo , Maria-José Chapela , Laurent Picot
Journal of Oceanography and Marine Research, 2018, 6 (3), pp.1000182. ⟨10.4172/2572-3103.1000182⟩
Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.
Alexandra Carvalho , Luana Heimfarth , Klécia Anjos , Adriana Gibara , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior
Phytomedicine, Elsevier, In press, ⟨10.1016/j.phymed.2018.10.028⟩
2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities
Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot , Lucille Vitek , Audrey Fleury , Valérie Thiéry , Mohamed Souab , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin
Tetrahedron, Elsevier, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩
From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines
Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin , Manon Boullard , Coline Courtel , Idriss Curbet , Clément Gédéon , Julien Lebreton , Laurent Picot , Valérie Thiéry , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin
Molecules, MDPI, 2018, 23 (11), ⟨10.3390/molecules23112961⟩
Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms
Raimundo Gonçalves de Oliveira Júnior , Christiane Adrielly Alves Ferraz , Jackson Roberto Guedes Da Silva Almeida , Raphäel Grougnet , Valérie Thiéry , Laurent Picot
Fitoterapia, Elsevier, In press, ⟨10.1016/j.fitote.2018.02.025⟩

2017

Article dans une revue

Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review
Raimundo Gonçalves Oliveira , Christiane Adrielly Alves Ferraz , Ana Paula Oliveira , Camila Souza Araújo , Layanne Feitosa da Silva Oliveira , Laurent Picot , Larissa Araújo Rolim , Pedro José Rolim-Neto , Jackson Roberto Guedes da Silva Almeida
Phytomedicine, Elsevier, 2017, ⟨10.1016/j.phymed.2017.08.017⟩
Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups
Benoît Serive , Elodie Nicolau , Jean-Baptiste Bérard , Raymond Kaas , Virginie Pasquet , Laurent Picot , Jean-Paul Cadoret , Adrianna Ianora
PLoS ONE, Public Library of Science, 2017, 12 (2), ⟨10.1371/journal.pone.0171872⟩
Antimelanoma activity of Heterocapsa triquetra pigments
Quentin Haguet , Antoine Bonnet , Jean-Baptiste Bérard , Joelle Goldberg , Nicolas Joguet , Audrey Fleury , Valérie Thiéry , Laurent Picot
Algal Research - Biomass, Biofuels and Bioproducts, Elsevier, 2017, 25, pp.207 - 215. ⟨10.1016/j.algal.2017.04.034⟩

Chapitre d'ouvrage

Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN
Raimundo Gonçalves de Oliveira Junior , Christiane Adrielly Alves Ferraz , Mariana Gama E Silva , Erica Martins de Lavor , Larissa Araújo Rolim , Julianeli Tolentino de Lima , Audrey Fleury , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior , Jackson Roberto Guedes da Silva Almeida
Natural Products and Cancer Drug Discovery , 2017
Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review
Renan Brito Guedes , P. Laise Santos , M. Almeida Oliveira , Lícia Tairiny Santos Pina , Angelo Roberto Antoniolli , Jackson Roberto Guedes da Silva Almeida , Gokhan Zengin , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior
Fibromyalgia and Peripheral Neuropathy , 2017

2016

Article dans une revue

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?
Raimundo Gonçalves Oliveira-Junior , Valérie Thiéry , Odile Sergent , Martine Chevanne , Laurent Picot
Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. ⟨10.4172/jomr.1000144 ⟩

2015

Article dans une revue

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines
Nada Marquise , Tan Tai Nguyen , Floris Chevallier , Laurent Picot , Valérie Thiéry , Olivier Lozach , Stéphane Bach , Sandrine Ruchaud , Florence Mongin
SYNLETT, Georg Thieme Verlag, 2015, 26, pp.2811-2816. ⟨10.1055/s-0035-1560496⟩
Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship
Mohamed Yacine Ameur Messaoud , Ghenia Bentabed-Ababsa , Madani Hedidi , Aïcha Derdour , Floris Chevallier , Yury S. Halauko , Oleg A. Ivashkevich , Vadim E. Matulis , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.1475-1485. ⟨10.3762/bjoc.11.160⟩
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.2541-2558. ⟨10.3390/md13042541⟩
Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.
Camille Juin , Jean-René Chérouvrier , Valérie Thiery , Anne-Laure Gagez , Jean-Baptiste Bérard , Nicolas, Joguet , Raymond Kaas , Jean-Paul Cadoret , Laurent Picot
Biotechnology and Applied Biochemistry, Wiley, 2015, ⟨10.1007/s12010-014-1250-2⟩
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.1541-2558. ⟨10.3390/md13042541⟩

2014

Article dans une revue

Lutter contre les cancers grâce aux pigments de microalgues
Laurent Picot
Biofutur, Elsevier - Cachan : Lavoisier, 2014
Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells
Madani Hedidi , Ghenia Bentabed-Ababsa , Aicha Derdour , Thierry Roisnel , Vincent Dorcet , Floris Chevallier , Laurent Picot , Valérie Thiery , Mongin Florence
Bioorg. Med. Chem., 2014, pp.1. ⟨10.1016/j.bmc.2014.04.028⟩

2013

Article dans une revue

Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation
Nada Marquise , Philip Harford , Floris Chevallier , Thierry Roisnel , Vincent Dorcet , Anne-Laure Gagez , Sophie Sablé , Laurent Picot , Valérie Thiéry , Andrew Wheatley , Philippe Gros , Florence Mongin
Tetrahedron, Elsevier, 2013, 69 (47), pp.10123-10133. ⟨10.1016/j.tet.2013.09.030⟩
Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
Paul-Hubert Baudelet , Anne-Laure Gagez , Jean-Baptiste Bérard , Camille Juin , Nicolas Bridiau , Raymond Kaas , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406
Towards the Clinical Use of Phytoplankton Carotenoid Pigments to Cure Cancer
Camille Juin , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot
oceanography, open access, 2013, 1 (3), ⟨10.4172/2332-2632.1000e105⟩

2012

Article dans une revue

The potential of microalgae for the production of bioactive molecules of pharmaceutical interest.
Virginie Mimouni , Lionel Ulmann , Virginie Pasquet , Marie Mathieu , Laurent Picot , Gaël Bougaran , Jean-Paul Cadoret , Annick Morant-Manceau , Benoît Schoefs
2012, 13 (15), pp.2733-2750

2011

Article dans une revue

Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts
Virginie Pasquet , Perrine Morisset , Saïd Ihammouine , Amandine Chepied , Lucie Aumailley , Jean-Baptiste Bérard , Benoît Serive , Raymond Kaas , Isabelle Lanneluc , Valérie Thiéry , Mathieu Lafferière , Jean-Marie Piot , Thierry Patrice , Jean-Paul Cadoret , Laurent Picot
Marine drugs, MDPI, 2011, 9, pp.819-831. ⟨10.3390/md9050819⟩

2010

Article dans une revue

Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties
Laurent Picot , Rozenn Ravallec , Martine Fouchereau-Peron , Laurent Vandanjon , Pascal Jaouen , Maryse Chaplain-Derouiniot , Fabienne Guérard , Aurelie Chabeaud , Yves Legal , Oscar Martinez Alvarez , Jean-Pascal Bergé , Jean-Marie Piot , Irineu Batista , Carla Pires , Gudjon Thorkelsson , Charles Delannoy , Greta Jakobsen , Inez Johansson , Patrick Bourseau
Journal of the Science of Food and Agriculture, Wiley, 2010, 90 (11), pp.1819-1826. ⟨10.1002/jsfa.4020⟩

2009

Article dans une revue

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives
Anne Beauchard , Alexis Jaunet , Laurence Murillo , Brigitte Baldeyrou , Amélie Lansiaux , Jean-René Chérouvrier , Lisianne Domon , Laurent Picot , Christian Bailly , Thierry Besson
European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (10), pp.3858-3865. ⟨10.1016/j.ejmech.2009.04.012⟩

2008

Article dans une revue

Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III
Alexandra Testard , Laurent Picot , Ingrid Fruitier-Arnaudin , Jean-Marie Piot , Hadjila Chabane , Lisianne Domon , Valérie Thiery , Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2008, 19 (6), pp.467-473. ⟨10.1080/14756360412331280491⟩

2005

Article dans une revue

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.
Alexandra Testard , Laurent Picot , Olivier Lozach , Melina Blairvacq , Laurent Meijer , Laurence Murillo , Jean-Marie Piot , Valérie Thiéry , Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩