Picot Laurent - LIttoral ENvironnement et Sociétés (LIENSs)

Flavonoids and their derivatives as DNA topoisomerase inhibitors with anti-cancer activity in various cell models: Exploring a novel mode of action

Przemysław Sitarek , Anna Merecz-Sadowska , Joanna Sikora , Malwina Dudzic , Natasza Wiertek-Płoszaj , Laurent Picot , Tomasz Śliwiński , Tomasz Kowalczyk

Pharmacological Research, 2024, 209 (9), pp.107457. ⟨10.1016/j.phrs.2024.107457⟩

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Phototoxicity of the Ethanolic Extract of Skeletonema marinoi for the Dermocosmetic Improvement of Acne

Jean-Baptiste Bérard , Tan-Sothea Ouk , Vincent Sol , Louise Lefoulon , Cornelia Landolt , Karine Grenier , Naima Saad , Elise Robert , Manoëlla Sibat , Nathalie Schreiber , Samuel Guenin , Laurent Picot

Marine drugs, 2024, 22 (8), pp.343. ⟨10.3390/md22080343⟩

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Deprotonative Metallation of Benzofuran and Benzothiophene Derivatives for the Formation of Tetracyclic and Pentacyclic Heteroaromatic Compounds

Loubna Elmir , Ghenia Bentabed-Ababsa , William Erb , Thierry Roisnel , Jean-Pierre Hurvois , Laurent Picot , Valérie Thiéry , Florence Mongin

European Journal of Organic Chemistry, 2024, 27 (27), ⟨10.1002/ejoc.202400374⟩

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The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy

Luiz Antonio Miranda de Souza Duarte Filho , Cintia Emi Yanaguibashi Leal , Pierre-Edouard Bodet , Edilson Beserra de Alencar Filho , Jackson Roberto Guedes da Silva Almeida , Manon Porta Zapata , Oussama Achour , Hugo Groult , Carlos Arthur Gouveia Veloso , Claudio Viegas Júnior , Nathalie Bourgougnon , Laurent Picot

Marine drugs, 2024, 22 (6), pp.244. ⟨10.3390/md22060244⟩

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The protective effects of naringenin, a citrus flavonoid, non-complexed or complexed with hydroxypropyl-β-cyclodextrin against multiorgan damage caused by neonatal endotoxemia

Luana Heimfarth , Katielen Silvana dos Santos , Brenda Souza Monteiro , Anne Karoline de Souza Oliveira , Henrique Douglas M. Coutinho , Irwin R.A. Menezes , Marcio Roberto Viana dos Santos , Adriano Antunes de Souza Araújo , Laurent Picot , Raimundo Gonçalves de Oliveira Júnior , Raphaël Grougnet , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans-Júnior

International Journal of Biological Macromolecules, 2024, 264, pp.130500. ⟨10.1016/j.ijbiomac.2024.130500⟩

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The Precious Potential of the Sacred Tree Chamaecyparis obtusa (Siebold & Zucc.) Endl. as a Source of Secondary Metabolites with Broad Biological Applications

Karol Maksymilian Górski , Tomasz Kowalczyk , Laurent Picot , Patricia Rijo , Mansour Ghorbanpour , Przemysław Sitarek

International Journal of Molecular Sciences, 2024, 25 (5), pp.2723. ⟨10.3390/ijms25052723⟩

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Anti-Inflammatory and Anticancer Effects of Anthocyanins in In Vitro and In Vivo Studies

Tomasz Kowalczyk , Martyna Muskała , Anna Merecz-Sadowska , Joanna Sikora , Laurent Picot , Przemysław Sitarek

Antioxidants , 2024, Natural Products: Biological, Antioxidant Properties and Health Effects—3rd Edition), 13 (9), pp.1143. ⟨10.3390/antiox13091143⟩

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The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone

Carlos Arthur Gouveia Veloso , César Augusto Gonçalves Dantas , Raimundo Gonçalves de Oliveira Júnior , Vicente Carlos de Oliveira Costa , Luiz Antonio Miranda de Souza Duarte-Filho , José Iranildo Miranda de Melo , Pierre Edouard Bodet , Josean Fechine Tavares , Marcelo Sobral da Silva , Laurent Picot

Phytochemistry Letters, 2024, 59, pp.45-52. ⟨10.1016/j.phytol.2023.12.004⟩

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In vitro antiherpetic activity of compounds extracted from Sargassum fluitans (Børgesen) Børgesen. Identification and in silico evaluation of potential antiviral molecules in a hydroalcoholic extract

Liena de Regla Ponce Rey , Hugo Pliego-Cortés , Christel Marty , Enrique Colina Araujo , Sonia Resik , Idania Rodeiro Guerra , Pierre Edouard Bodet , Laurent Picot , Nathalie Bourgougnon

Journal of Applied Phycology, 2024, ⟨10.1007/s10811-024-03202-4⟩

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Anti-melanoma potential of inclusion complexes containing phyllacanthone in β-cyclodextrin and sulfobutyl-ether-β-cyclodextrin

Cristiane dos Santos Cerqueira Alves , Yuri Kelvin Silva Camacho Tavares , Guilherme Urias Menezes Novaes , Victória Laysna dos Anjos Santos , Ana Paula de Oliveira , Cintia Emi Yanaguibashi Leal , Edilson Beserra de Alencar Filho , Christiane Adrielly Alves Ferraz , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Raimundo Gonçalves de Oliveira Júnior

Journal of Drug Delivery Science and Technology, 2023, 89, pp.105020. ⟨10.1016/j.jddst.2023.105020⟩

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The decapod crustacean fauna from the Late Jurassic of Cricqueboeuf, Normandy (France)

Sylvain Charbonnier , Alessandro Garassino , Damien Gendry , Julien Devillez , Laurent Picot

Geodiversitas, 2023, 45 (19), ⟨10.5252/geodiversitas2023v45a19⟩

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Biological effect of natural chitosan nanoparticles with transformed roots extract of Leonotis nepetifolia (L.) R.Br. in an in vitro model

Tomasz Kowalczyk , Monika Owczarek , Ewelina Synowiec , Tomasz Śliwiński , Anna Merecz-Sadowska , Laurent Picot , Przemysław Sitarek

Industrial Crops and Products, 2023, 203, pp.117135. ⟨10.1016/j.indcrop.2023.117135⟩

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Ligand fishing as a tool to screen natural products with anticancer potential

Luiz Antonio Miranda de Souza Duarte-Filho , Pamella Christina Ortega de Oliveira , Cíntia Emi Yanaguibashi Leal , Marcela Cristina de Moraes , Laurent Picot

Journal of Separation Science, 2023, 46 (12), pp.2200964. ⟨10.1002/jssc.202200964⟩

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From benzofuro-, benzothieno- and 10-methylindolo-[2,3-b]-fused benzothiopyrano[4,3,2-de]quinolines to the corresponding benzothiopyrano[4,3,2-de]1,8-naphthyridines: synthesis and properties of these hexacyclic heteroaromatic compounds

Nicolas Mast , William Erb , Lionel Nauton , Pascale Moreau , Olivier Mongin , Thierry Roisnel , Margaux Macaigne , Thomas Robert , Stéphane Bach , Laurent Picot , Valérie Thiéry , Jean-Pierre Hurvois , Florence Mongin

New Journal of Chemistry, 2023, 47 (1), pp.258-283. ⟨10.1039/D2NJ04567B⟩

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A review of phototoxic plants, their phototoxic metabolites, and possible developments as photosensitizers.

Raphaelle Petit , Jonathan Izambart , Mathieu Guillou , Jackson Guedes da Silva Almeida , Raimundo Gonçalves de Oliveira Junior , Vincent Sol , Tan-Sothea Ouk , Raphael Grougnet , Lucindo Quintans-Junior , Przemyslaw Sitarek , Valérie Thiéry , Laurent Picot

Chemistry and Biodiversity, 2023, ⟨10.1002/cbdv.202300494⟩

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Les crustacés de l'Oxfordien supérieur de Cricqueboeuf (Normandie, France)

Sylvain Charbonnier , Alessandro Garassino , Damien Gendry , Julien Devillez , Laurent Picot

28e Réunion des Sciences de la Terre, Université de Rennes; Société Géologique de France, Oct 2023, Rennes, France

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Bisphosphonylallenes as Suitable Scaffolds for Unprecedented 4,5-Diphosphonyldihydropyridazines and 3,4-Diphosphonylpyrroles Displaying Antimelanoma Activity

Kmar Abaid , William Erb , David Virieux , Laurent Picot , Benjamin Musnier , Valérie Thiéry , Thierry Roisnel , Florence Mongin , Soufiane Touil

ACS Omega, 2022, 7 (43), pp.38894-38901. ⟨10.1021/acsomega.2c04619⟩

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Anticancer Properties of Plectranthus ornatus-Derived Phytochemicals Inducing Apoptosis via Mitochondrial Pathway

Przemysław Sitarek , Ewelina Synowiec , Tomasz Kowalczyk , Gabrielle Bangay , Tomasz Śliwiński , Laurent Picot , Salvatore Princiotto , Patricia Rijo

International Journal of Molecular Sciences, 2022, 23 (19), pp.11653. ⟨10.3390/ijms231911653⟩

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Carotenoids from Marine Microalgae as Antimelanoma Agents

Christiane Adrielly Alves Ferraz , Raphaël Grougnet , Elodie Nicolau , Laurent Picot , Raimundo Gonçalves de Oliveira Junior

Marine drugs, 2022, 20 (10), pp.618. ⟨10.3390/md20100618⟩

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Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential

Antoine Grivard , Isabelle Goubet , Luiz Miranda de Souza Duarte Filho , Valérie Thiéry , Sylvie Chevalier , Raimundo Gonçalves de Oliveira Júnior , Noureddine El Aouad , Jackson Roberto Guedes da Silva Almeida , Przemysław Sitarek , Lucindo José Quintans-Junior , Raphaël Grougnet , Hélène Agogué , Laurent Picot

Marine drugs, 2022, Marine Pigments, 20 (8), pp.524. ⟨10.3390/md20080524⟩

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First description of the most complete Metriorhynchus aff. superciliosus (Thalattosuchia) specimen from the Callovian of the Vaches-Noires cliffs (Normandy, France) and limitations in the classification of Metriorhynchidae

Jonas Le Mort , Jeremy Martin , Laurent Picot , Stéphane Hua

Annales de Paléontologie, 2022, 108 (3), pp.102539. ⟨10.1016/j.annpal.2022.102539⟩

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Fucoxanthin from Algae to Human, an Extraordinary BioreSource: Insights and Advances in up and Downstream Processes

Anne Pajot , Gia Hao Huynh , Laurent Picot , Luc Marchal , Elodie Nicolau

Marine drugs, 2022, 20 (4), pp.222. ⟨10.3390/md20040222⟩

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New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

Evariste Monvoisin , Ronan Allain , Eric Buffetaut , Laurent Picot

Geodiversitas, 2022, 44 (12), ⟨10.5252/geodiversi-tas2022v44a12⟩

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Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAFmutated melanoma cells

Raimundo Gonçalves de Oliveira-Júnior , Christiane Adrielly Alves Ferraz , Ana Paula de Oliveira , Edigênia Cavalcante da Cruz Araújo , Grégoire Prunier , Laureen Beaugeard , Hugo Groult , Laurent Picot , Edilson Beserra de Alencar Filho , Noureddine El Aouad , Larissa Araújo Rolim , Jackson Roberto Guedes da Silva Almeida

Chemico-Biological Interactions, 2022, 355, pp.109849. ⟨10.1016/j.cbi.2022.109849⟩

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Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

Tomasz Kowalczyk , Anna Merecz-Sadowska , Laurent Picot , Irena Brčić Karačonji , Joanna Wieczfinska , Tomasz Śliwiński , Przemysław Sitarek

Molecules, 2022, 27 (3), pp.795. ⟨10.3390/molecules27030795⟩

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The Franco-Brazilian network on natural products (FB2NP): a new network promoting cooperation and exchanges in natural products research

Jackson Almeida , Raphaël Grougnet , Lucindo Quintans , Sylvie Chevalier , Marc Feuilloley , Thomas Robert , Stéphane Bach , Raimundo Oliveira , Valérie Thiéry , Jean-Pierre Bazureau , Florence Mongin , Marina Kritsanida , Vincent Sol , Vicente Costa , Nathalie Bourgougnon , Pascal Marchand , Laurent Picot

Química Nova, 2022, 45, pp.1-3. ⟨10.21577/0100-4042.20170847⟩

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Thiazolo[5,4- f ]quinoxalines, Oxazolo[5,4- f ]quinoxalines and Pyrazino[ b,e ]isatins: Synthesis from 6-Aminoquinoxalines and Properties

Frédéric Lassagne , Joshua M. Sims , William Erb , Olivier Mongin , Nicolas Richy , Nour El Osmani , Ziad Fajloun , Laurent Picot , Valérie Thiéry , Thomas Robert , Stéphane Bach , Vincent Dorcet , Thierry Roisnel , Florence Mongin

European Journal of Organic Chemistry, 2021, 2021 (19), pp.2756-2763. ⟨10.1002/ejoc.202100362⟩

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Anticancer activity of limonene: A systematic review of target signaling pathways

Heitor Gomes De Araújo‐filho , Jucilene Santos , Mikaella Carvalho , Laurent Picot , Ingrid Fruitier-Arnaudin , Hugo Groult , Lucindo Quintans‐júnior , Jullyana S.S. Quintans

Phytotherapy Research, 2021, ⟨10.1002/ptr.7125⟩

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Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways

Fabiolla Rocha Santos Passos , Erik W.M. Pereira , Luana Heimfarth , Brenda Monteiro , Yasmim Maria Barbosa Gomes de Carvalho , Pollyana Siqueira-Lima , Henrique Douglas Melo Coutinho , Adriano Antunes de Souza Araújo , Jackson Roberto Guedes da Silva Almeida , Rosana S.S. Barreto , Laurent Picot , Lucindo Quintans-Júnior , Jullyana S.S. Quintans

Neuropharmacology, 2021, 186, pp.108395. ⟨10.1016/j.neuropharm.2020.108395⟩

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Chemical composition and biological potential of a chloroform fraction from the leaves of marine plant Syringodium filiforme Kützing

Kethia Gonzalez , David Marrero , Yasnay Hernández , Yulexi Acosta Suarez , Richard Gutiérrez Cuesta , Mario Riera-Romo , Olga Echemendia , Lívia Macedo Dutra , Jackson Roberto Guedes da Silva Almeida , Dayana Pérez-Martínez , Laurent Picot , Idania Rodeiro Guerra

Pharmacognosy Magazine, 2021, 16 (72), pp.750-756. ⟨10.4103/pm.pm_24_20⟩

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Preliminary Phytochemical Analysis and Evaluation of the Biological Activity of Leonotis nepetifolia (L.) R. Br Transformed Roots Extracts Obtained through Rhizobium rhizogenes-Mediated Transformation

Tomasz Kowalczyk , Anna Merecz-Sadowska , Patricia Rijo , Vera M S Isca , Laurent Picot , Marzena Wielanek , Tomasz Śliwiński , Przemysław Sitarek

Cells, 2021, 10 (5), pp.1242. ⟨10.3390/cells10051242⟩

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Iodothiophenes and Related Compounds as Coupling Partners in Copper-Mediated N-Arylation of Anilines

Salima Bouarfa , Ghenia Bentabed-Ababsa , William Erb , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Synthesis: Journal of Synthetic Organic Chemistry, 2021, 53 (07), pp.1271-1284. ⟨10.1055/s-0040-1706542⟩

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Improving Microalgae Research and Marketing in the European Atlantic Area: Analysis of Major Gaps and Barriers Limiting Sector Development

Judith Rumin , Raimundo Gonçalves de Oliveira Junior , Jean-Baptiste Bérard , Laurent Picot

Marine drugs, 2021, 19 (6), pp.319. ⟨10.3390/md19060319⟩

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Updated pigment composition of Tisochrysis lutea and purification of fucoxanthin using centrifugal partition chromatography coupled to flash chromatography for the chemosensitization of melanoma cells

Raimundo Gonçalves de Oliveira-Júnior , Raphaël Grougnet , Pierre-Edouard Bodet , Antoine Bonnet , Elodie Nicolau , Ahlem Jebali , Judith Rumin , Laurent Picot

Algal Research - Biomass, Biofuels and Bioproducts, 2020, 51, pp.102035. ⟨10.1016/j.algal.2020.102035⟩

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2-Aminobenzaldehyde, a common precursor to acridines and acridones endowed with bioactivities

Sarah Zeghada , Ghenia Bentabed-Ababsa , Olivier Mongin , William Erb , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Tetrahedron, 2020, 76 (38), pp.131435. ⟨10.1016/j.tet.2020.131435⟩

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Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement

Heitor Araújo-Filho , Erik W.M. Pereira , Luana Heimfarth , Brenda Souza Monteiro , Fabiolla Rocha Santos Passos , Pollyana Siqueira-Lima , Sathiyabama Gandhi , Márcio Roberto Viana dos Santos , Jackson Roberto Guedes da Silva Almeida , Laurent Picot , Raphaël Grougnet , Ray Almeida , Henrique Douglas Melo Coutinho , Lucindo Quintans-Júnior , Natália Martins , Jullyana S.S. Quintans

International Immunopharmacology, 2020, 86, pp.106766. ⟨10.1016/j.intimp.2020.106766⟩

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Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells

Christiane Adrielly Alves Ferraz , Raimundo Gonçalves de Oliveira Júnior , Ana Paula de Oliveira , Hugo Groult , Laureen Beaugeard , Laurent Picot , Edilson Beserra de Alencar Filho , Jackson Roberto Guedes da Silva Almeida , Xirley Pereira Nunes

European Journal of Pharmaceutical Sciences, 2020, 150, pp.105353. ⟨10.1016/j.ejps.2020.105353⟩

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Polymethoxyflavones from Gardenia oudiepe (Rubiaceae) induce cytoskeleton disruption-mediated apoptosis and sensitize BRAF-mutated melanoma cells to chemotherapy

Raimundo Gonçalves de Oliveira-Júnior , Nolwenn Marcoult-Fréville , Grégoire Prunier , Laureen Beaugeard , Edilson Beserra de Alencar Filho , Eduard David Simões Mourão , Sylvie Michel , Lucindo José Quintans-Júnior , Jackson Roberto Guedes da Silva Almeida , Raphaël Grougnet , Laurent Picot

Chemico-Biological Interactions, 2020, 325, pp.109109. ⟨10.1016/j.cbi.2020.109109⟩

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Analysis of Scientific Research Driving Microalgae Market Opportunities in Europe

Judith Rumin , Elodie Nicolau , Raimundo Gonçalves de Oliveira Junior , Claudio Fuentes-Grünewald , Laurent Picot

Marine drugs, 2020, 18 (5), pp.264. ⟨10.3390/md18050264⟩

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Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6

Alexandra Carvalho , Luana Heimfarth , Erik Willyame Menezes Pereira , Fabrício Santana Oliveira , Irwin Menezes , Henrique Coutinho , Laurent Picot , Angelo Roberto Antoniolli , Jullyana Quintans , Lucindo Quintans-Júnior

Journal of Natural Products, 2020, 83 (4), pp.1107-1117. ⟨10.1021/acs.jnatprod.9b01116⟩

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Carotenoids from Rhodomonas salina Induce Apoptosis and Sensitize A2058 Melanoma Cells to Chemotherapy

Raimundo Gonçalves de Oliveira-Júnior , Élodie Nicolau , Antoine Bonnet , Grégoire Prunier , Laureen Beaugeard , Nicolas Joguet , Valérie Thiéry , Laurent Picot

Revista Brasileira de Farmacognosia, 2020, 30 (2), pp.155-168. ⟨10.1007/s43450-020-00036-2⟩

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An Extract of Transgenic Senna obtusifolia L. hairy roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

Tomasz Kowalczyk , Przemysław Sitarek , Monika Toma , Laurent Picot , Marzena Wielanek , Ewa Skała , Tomasz Śliwiński

Biomolecules, 2020, 10 (4), pp.510. ⟨10.3390/biom10040510⟩

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A Bibliometric Analysis of Microalgae Research in the World, Europe, and the European Atlantic Area

Judith Rumin , Elodie Nicolau , Raimundo Gonçalves de Oliveira Junior , Claudio Fuentes-Grünewald , Kevin J. Flynn , Laurent Picot

Marine drugs, 2020, 18 (2), pp.79. ⟨10.3390/md18020079⟩

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Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest

Nahida Mokhtari Brikci-Nigassa , Lionel Nauton , Pascale Moreau , Olivier Mongin , Raphael E Duval , Laurent Picot , Valérie Thiery , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Rémy Le Guével , Ghenia Bentabed-Ababsa , William Erb , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Bioorganic Chemistry, 2020, 94, pp.103347. ⟨10.1016/j.bioorg.2019.103347⟩

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Thermophysiologies of Jurassic marine crocodylomorphs inferred from the oxygen isotope composition of their tooth apatite

Nicolas Séon , Romain Amiot , Jérémy Martin , Mark Young , Heather Middleton , François Fourel , Laurent Picot , Xavier Valentin , Christophe Lécuyer

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020, 375 (1793), pp.20190139. ⟨10.1098/rstb.2019.0139⟩

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Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review

Christiane Adrielly Alves Ferraz , Raimundo Gonçalves de Oliveira Júnior , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Xirley Pereira Nunes

Fitoterapia, 2019, 137, pp.104196. ⟨10.1016/j.fitote.2019.104196⟩

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Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.

Alexandra M.S. Carvalho , Luana Heimfarth , Klécia Anjos , Adriana Gibara , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior

Phytomedicine, 2019, 57, pp.137-147. ⟨10.1016/j.phymed.2018.10.028⟩

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From ecological relevance of the ecosystem services concept to its socio-political use. The case study of intertidal bare mudflats in the Marennes-Oléron Bay, France

Benoit Lebreton , Audrey Rivaud , Laurent Picot , Benoît Prévost , Laurent Barillé , Thierry Sauzeau , Jennifer Beseres Pollack , Johann Lavaud

Ocean and Coastal Management, 2019, 172, pp.41-54. ⟨10.1016/j.ocecoaman.2019.01.024⟩

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An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity

Ewa Skała , Laurent Picot , Michał Bijak , Joanna Bijak , Janusz Szemraj , Agnieszka Kicel , Monika Olszewska , Przemysław Sitarek

Industrial Crops and Products, 2019, 129, pp.327-338. ⟨10.1016/j.indcrop.2018.12.020⟩

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Chemical constituents of non-polar fractions obtained from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant native to Caatinga biome Chemical constituents of non-polar fractions obtained from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant native to Caatinga biome

Raimundo G. de Oliveira-Júnior , Christiane Adrielly A. Ferraz , Ana Paula de Oliveira , José Marcos T. de Alencar-Filho , Edigênia C. C. Araújo , Xirley P. Nunes , Laurent Picot , Norberto P Lopes , Raimundo Braz-Filho , Larissa A. Rolim , Jackson Roberto G. da S. Almeida

Revista Virtual de Química, 2019, 11 (2), pp.498-516. ⟨10.21577/1984-6835.20190038⟩

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Crystal Structure of 6,7-Dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-dione

Jean Guillon , Maria de Fatima Pereira-Rosenfeld , Noël Pinaud , Thierry Besson , Valérie Thiéry , Laurent Picot , Mathieu Marchivie

X-Ray Structure Analysis Online, 2019, 35 (10), pp.57-59. ⟨10.2116/xraystruct.35.57⟩

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Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity

Raimundo Gonçalves de Oliveira Júnior , Antoine Bonnet , Estelle Braconnier , Hugo Groult , Grégoire Prunier , Laureen Beaugeard , Raphäel Grougnet , Jackson Roberto Guedes da Silva Almeida , Christiane Adrielly Alves Ferraz , Laurent Picot

Food and Chemical Toxicology, 2019, 125, pp.549-561. ⟨10.1016/j.fct.2019.02.013⟩

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Monoterpenes modulating cytokines - A review

Jullyana S.S. Quintans , Saravanan Shanmugam , Luana Heimfarth , Adriano Antunes S. Araújo , Jackson R.G.da S. Almeida , Laurent Picot , Lucindo J Quintans-Júnior

Food and Chemical Toxicology, 2019, 123, pp.233-257. ⟨10.1016/j.fct.2018.10.058⟩

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Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review

Priscila Santos , João Pedro S.C.F. Matos , Laurent Picot , Jackson R.G.S. Almeida , Jullyana S.S. Quintans , Lucindo J. Quintans-Junior

Food and Chemical Toxicology, 2019, 123, pp.459-469. ⟨10.1016/j.fct.2018.11.030⟩

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Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome

Raimundo Gonçalves de Oliveira-Júnior , Christiane Adrielly Alvez Ferraz , Michelle Cruz Pontes , Noelly Bastos Cavalcante , Edigênia Cavalcante da Cruz Araújoa , Ana Paula de Oliveira , Laurent Picot , Larissa Araújo Rolim , Jackson Roberto Guedes da Silva Almeida

European Journal of Integrative Medicine, 2018, 24, pp.30-34. ⟨10.1016/j.eujim.2018.10.011⟩

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From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin , Manon Boullard , Coline Courtel , Idriss Curbet , Clément Gédéon , Julien Lebreton , Laurent Picot , Valérie Thiéry , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin

Molecules, 2018, 23 (11), pp.2961. ⟨10.3390/molecules23112961⟩

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Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity

Przemysław Sitarek , Tomasz Kowalczyk , Laurent Picot , Dorota Michalska-Hejduk , Michał Bijak , Adam J Białas , Marzena Wielanek , Tomasz Śliwiński , Ewa Skała

Industrial Crops and Products, 2018, 122, pp.732 - 739. ⟨10.1016/j.indcrop.2018.06.059⟩

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Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms

Raimundo Gonçalves de Oliveira Júnior , Christiane Adrielly Alves Ferraz , Jackson Roberto Guedes da Silva Almeida , Raphäel Grougnet , Valérie Thiéry , Laurent Picot

Fitoterapia, 2018, 129, pp.383-400. ⟨10.1016/j.fitote.2018.02.025⟩

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EnhanceMicroalgae: An European Interregional Project Stimulating Research, Innovation, Industrial Development and Transnational Cooperation within the Atlantic Area Microalgae Sector

Judith Rumin , Joana Martins , Jose Cruz , Vitor Vasconcelos , Claudio Fuentes Grünewald , Kevin J. Flynn , Alejandra Sabin , Maria Paredes , Enma Conde , Jose Vilarino , Martina Ferreira , Federica Farabegoli , Paula Fajardo , Maria-José Chapela , Laurent Picot

Journal of Oceanography and Marine Research, 2018, 6 (3), pp.1000182. ⟨10.4172/2572-3103.1000182⟩

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2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot , Lucille Vitek , Audrey Fleury , Valérie Thiéry , Mohamed Souab , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin

Tetrahedron, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩

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Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib

Camille Juin , Raimundo Gonçalves de Oliveira Junior , Audrey Fleury , Chloé Oudinet , Lior Pytowski , Jean-Baptiste Bérard , Elodie Nicolau , Valérie Thiéry , Isabelle Lanneluc , Laureen Beaugeard , Grégoire Prunier , Jackson Roberto Guedes da Silva Almeida , Laurent Picot

Revista Brasileira de Farmacognosia, 2018, 28 (4), pp.457-467. ⟨10.1016/j.bjp.2018.05.009⟩

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Natural compounds targeting pyocyanin and quorum sensing in Pseudomonas aeruginosa

Ali Tahrioui , Onyedikachi Cecil Azuama , Sergio Ortiz , Raimundo Gonçalves , Damien Tortuel , Olivier Maillot , Chouaha Bouzidi , Laurent Picot , Raphaël Grougnet , Sabrina Boutefnouchet , Marina Kritsanida , Marc Feuilloley , Nicole Orange , Sylvie Michel , Olivier Lesouhaitier , Emeline Bouffartigues , Sylvie Chevalier

Congrès National de la Société Française de Microbiologie-SFM2018, Oct 2018, Paris, France

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Potential of Optical Frequency Domain Reflectometry fiber-based sensors for distributed temperature measurements during vacuum thermal cycling of satellites

Camille Sabatier , Adriana Morana , Sylvain Girard , Aziz Boukenter , Y. Ouerdane , Emmanuel Marin , Thierry Robin , Benoît Cadier , Olivier Gilard , Laurent Picot

European Workshop on Structural Health Monitoring Series (EWSHM 2018), Jul 2018, Manchester, United Kingdom. pp.0307

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Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review

Raimundo Gonçalves Oliveira , Christiane Adrielly Alves Ferraz , Ana Paula Oliveira , Camila Souza Araújo , Layanne Feitosa da Silva Oliveira , Laurent Picot , Larissa Araújo Rolim , Pedro José Rolim-Neto , Jackson Roberto Guedes da Silva Almeida

Phytomedicine, 2017, ⟨10.1016/j.phymed.2017.08.017⟩

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Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups

Benoît Serive , Elodie Nicolau , Jean-Baptiste Bérard , Raymond Kaas , Virginie Pasquet , Laurent Picot , Jean-Paul Cadoret , Adrianna Ianora

PLoS ONE, 2017, 12 (2), ⟨10.1371/journal.pone.0171872⟩

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Antimelanoma activity of Heterocapsa triquetra pigments

Quentin Haguet , Antoine Bonnet , Jean-Baptiste Bérard , Joelle Goldberg , Nicolas Joguet , Audrey Fleury , Valérie Thiéry , Laurent Picot

Algal Research - Biomass, Biofuels and Bioproducts, 2017, 25, pp.207 - 215. ⟨10.1016/j.algal.2017.04.034⟩

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Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN

Raimundo Gonçalves de Oliveira Junior , Christiane Adrielly Alves Ferraz , Mariana Gama E Silva , Erica Martins de Lavor , Larissa Araújo Rolim , Julianeli Tolentino de Lima , Audrey Fleury , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior , Jackson Roberto Guedes da Silva Almeida

Natural Products and Cancer Drug Discovery , 2017

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Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review

Renan Brito Guedes , P. Laise Santos , M. Almeida Oliveira , Lícia Tairiny Santos Pina , Angelo Roberto Antoniolli , Jackson Roberto Guedes da Silva Almeida , Gokhan Zengin , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior

Fibromyalgia and Peripheral Neuropathy , 2017

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Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

Raimundo Gonçalves Oliveira-Junior , Valérie Thiéry , Odile Sergent , Martine Chevanne , Laurent Picot

Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. ⟨10.4172/jomr.1000144⟩

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Les chondrichthyens de la sériecallovo-oxfordoenne de Normandie

Marjolaine Furic , Jean-Philippe Pezy , Elisabeth Pennetier , Gérard Pennetier, , M.C. Perchey , Romain Vullo , Laurent Picot

25e Réunion des Sciences de la Terre, Société Géologique de France, Oct 2016, Caen, France. pp.134

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The implementation of taxonomic harmonisation for Candoninae (Ostracoda, Cypridoidea): A heuristic solution for Fabaeformiscandona tricicatricosa (Diebel and Pietrzeniuk)

D.L. Danielopol , Tadeusz Namiotko , Ulrich von Grafenstein , Roland Fuhrmann , Laurent Decrouy , Martin Gross , Maria Pichler , Laurent Picot

Geo-Eco-Marina, 2015, 21, pp.111-158

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Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines

Nada Marquise , Tan Tai Nguyen , Floris Chevallier , Laurent Picot , Valérie Thiéry , Olivier Lozach , Stéphane Bach , Sandrine Ruchaud , Florence Mongin

SYNLETT, 2015, 26 (20), pp.2811-2816. ⟨10.1055/s-0035-1560496⟩

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Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship

Mohamed Yacine Ameur Messaoud , Ghenia Bentabed-Ababsa , Madani Hedidi , Aïcha Derdour , Floris Chevallier , Yury S. Halauko , Oleg A. Ivashkevich , Vadim E. Matulis , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Beilstein Journal of Organic Chemistry, 2015, 11, pp.1475-1485. ⟨10.3762/bjoc.11.160⟩

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Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.

Camille Juin , Jean-René Chérouvrier , Valérie Thiery , Anne-Laure Gagez , Jean-Baptiste Bérard , Nicolas, Joguet , Raymond Kaas , Jean-Paul Cadoret , Laurent Picot

Biotechnology and Applied Biochemistry, 2015, ⟨10.1007/s12010-014-1250-2⟩

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UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum

Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

Marine drugs, 2015, 13 (4), pp.1541-2558. ⟨10.3390/md13042541⟩

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Lutter contre les cancers grâce aux pigments de microalgues

Laurent Picot

Biofutur, 2014

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Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

Madani Hedidi , Ghenia Bentabed-Ababsa , Aicha Derdour , Thierry Roisnel , Vincent Dorcet , Floris Chevallier , Laurent Picot , Valérie Thiery , Mongin Florence

Bioorganic and Medicinal Chemistry, 2014, 22 (13), pp.3498-3507. ⟨10.1016/j.bmc.2014.04.028⟩

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Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation

Nada Marquise , Philip J. Harford , Floris Chevallier , Thierry Roisnel , Vincent Dorcet , Anne-Laure Gagez , Sophie Sablé , Laurent Picot , Valérie Thiéry , Andrew E. H. Wheatley , Philippe C. Gros , Florence Mongin

Tetrahedron, 2013, 69 (47), pp.10123-10133. ⟨10.1016/j.tet.2013.09.030⟩

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Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

Paul-Hubert Baudelet , Anne-Laure Gagez , Jean-Baptiste Berard , Camille Juin , Nicolas Bridiau , Raymond Kaas , Valerie Thiery , Jean-Paul Cadoret , Laurent Picot

Marine drugs, 2013, 11 (11), pp.4390-4406. ⟨10.3390/md11114390⟩

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Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

Paul-Hubert Baudelet , Anne-Laure Gagez , Jean-Baptiste Bérard , Camille Juin , Nicolas Bridiau , Raymond Kaas , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

Marine drugs, 2013, 11 (11), pp.4390-4406

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Towards the Clinical Use of Phytoplankton Carotenoid Pigments to Cure Cancer

Camille Juin , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

oceanography, open access, 2013, 1 (3), ⟨10.4172/2332-2632.1000e105⟩

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Une approche numérique pour la simulation d´un examen de mammographie

Hervé Drobez , Hervé Reynaud , Laurent Picot , Haidar Jaffal , Virginie Corre , Remy Klausz , Serge Muller

CFM 2013 - 21ème Congrès Français de Mécanique, Aug 2013, Bordeaux, France

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The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest

Virginie Mimouni , Lionel Ulmann , Virginie Pasquet , Marie Mathieu , Laurent Picot , Gaël Bougaran , Jean-Paul Cadoret , Annick Morant-Manceau , Benoît Schoefs

Current Pharmaceutical Biotechnology, 2012, 13 (15), pp.2733-2750. ⟨10.2174/138920112804724828⟩

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Selection and optimisation of a method for efficient metabolites extraction from microalgae

Benoit Serive , Raymond Kaas , Jean-Baptiste Berard , Virginie Pasquet , Laurent Picot , Jean-Paul Cadoret

Bioresource Technology, 2012, 124, pp.311-320. ⟨10.1016/j.biortech.2012.07.105⟩

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Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts

Virginie Pasquet , Perrine Morisset , Saïd Ihammouine , Amandine Chepied , Lucie Aumailley , Jean-Baptiste Bérard , Benoît Serive , Raymond Kaas , Isabelle Lanneluc , Valérie Thiéry , Mathieu Lafferriere , Jean-Marie Piot , Thierry Patrice , Jean-Paul Cadoret , Laurent Picot

Marine drugs, 2011, 9 (5), pp.819-831. ⟨10.3390/md9050819⟩

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Study on the microalgal pigments extraction process: Performance of microwave assisted extraction

Virginie Pasquet , Jean-Rene Cherouvrier , Firas Farhat , Valerie Thiery , Jean-Marie Piot , Jean-Baptiste Berard , Raymond Kaas , Benoit Serive , Thierry Patrice , Jean-Paul Cadoret , Laurent Picot

Process Biochemistry, 2011, 46 (1), pp.59-67. ⟨10.1016/j.procbio.2010.07.009⟩

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Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts

Virginie Pasquet , Perrine Morisset , Saïd Ihammouine , Amandine Chepied , Lucie Aumailley , Jean-Baptiste Bérard , Benoît Serive , Raymond Kaas , Isabelle Lanneluc , Valérie Thiéry , Mathieu Lafferière , Jean-Marie Piot , Thierry Patrice , Jean-Paul Cadoret , Laurent Picot

Marine drugs, 2011, 9, pp.819-831. ⟨10.3390/md9050819⟩

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Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties

Laurent Picot , Rozenn Ravallec , Martine Fouchereau-Peron , Laurent Vandanjon , Pascal Jaouen , Maryse Chaplain-Derouiniot , Fabienne Guérard , Aurelie Chabeaud , Yves Legal , Oscar Martinez Alvarez , Jean-Pascal Bergé , Jean-Marie Piot , Irineu Batista , Carla Pires , Gudjon Thorkelsson , Charles Delannoy , Greta Jakobsen , Inez Johansson , Patrick Bourseau

Journal of the Science of Food and Agriculture, 2010, 90 (11), pp.1819-1826. ⟨10.1002/jsfa.4020⟩

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Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives

Anne Beauchard , Alexis Jaunet , Laurence Murillo , Brigitte Baldeyrou , Amélie Lansiaux , Jean-René Chérouvrier , Lisianne Domon , Laurent Picot , Christian Bailly , Thierry Besson

European Journal of Medicinal Chemistry, 2009, 44 (10), pp.3858-3865. ⟨10.1016/j.ejmech.2009.04.012⟩

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Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III

Alexandra Testard , Laurent Picot , Ingrid Fruitier-Arnaudin , Jean-Marie Piot , Hadjila Chabane , Lisianne Domon , Valérie Thiery , Thierry Besson

Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 19 (6), pp.467-473. ⟨10.1080/14756360412331280491⟩

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Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

François Liger , Florence Popowycz , Thierry Besson , Laurent Picot , Carlos Galmarini , Benoît Joseph

Bioorganic and Medicinal Chemistry Letters, 2007, 15 (16), pp.5615-5619. ⟨10.1016/j.bmc.2007.05.033⟩

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Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.

Alexandra Testard , Laurent Picot , Olivier Lozach , Melina Blairvacq , Laurent Meijer , Laurence Murillo , Jean-Marie Piot , Valérie Thiéry , Thierry Besson

Journal of Enzyme Inhibition and Medicinal Chemistry, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩

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Regulation of the cytotoxic effects of Pseudomonas fluorescens by growth temperature

Laurent Picot , Sana Mezghani-Abdelmoula , Sylvie Chevalier , Annabelle Merieau , Olivier Lesouhaitier , Josette Guerillon , Lionel Cazin , Nicole Orange , Marc G.J. Feuilloley

Research in Microbiology, 2004, 155 (1), pp.39-46. ⟨10.1016/j.resmic.2003.09.014⟩

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Cytotoxic effects of the lipopolysaccharide from Pseudomonas fluorescens on neurons and glial cells

Laurent Picot , Sylvie Chevalier , Sana Mezghani-Abdelmoula , Annabelle Mérieau , Olivier Lesouhaitier , Philippe Leroux , Lionel Cazin , Nicole Orange , Marc G.J Feuilloley

Microbial Pathogenesis, 2003, 35 (3), pp.95-106. ⟨10.1016/s0882-4010(03)00092-5⟩

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Pseudomonas fluorescens as a potential pathogen: adherence to nerve cells

Laurent Picot , Sana Mezghani Abdelmoula , Annabelle Mérieau , Philippe Leroux , Lionel Cazin , Nicole Orange , Marc G.J Feuilloley

Microbes and Infection, 2001, 3 (12), pp.985-995. ⟨10.1016/s1286-4579(01)01462-9⟩

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