Picot Laurent, MCF-HDR
- Équipe de rattachement : BCBS
- Statut : Chercheur
- laurent.picot@univ-lr.fr
- Tél. : +33 (0)5 46 45 82 20
Enseignant-chercheur, Maître de Conférences
Université de La Rochelle
Section de Recherche : CNU 64
Institut scientifique du CNRS référent : INEE
Mots clés : Anticancéreux, microalgues marines, pigments, hétérocycles, pharmacologie
- Animateur des thématiques de recherche "Pigments marins et Photothérapie dynamique des tumeurs" et "Composition et activité pharmacologique de plantes terrestres Brésiliennes"
- Responsable pour l’université de La Rochelle du Projet Européen Interreg Enhance Microalgae
- Editeur invité numéro spécial "Antiproliferative Marine Natural products" de la revue "Marine Drugs"
Thèmes de Recherche.
- Recherche d’anticancéreux dans l’environnement marin, pharmacologie des anticancéreux
- Extraction, purification, caractérisation moléculaire, activité pharmacologique de pigments de microalgues marines et de plantes terrestres
- Valorisation biotechnologique des ressources marines et botaniques en cancérologie
- Anticancéreux hétérocycliques
 |
 |
 |
|---|
Liste des publications :
27 résultats
2018
Article dans une revue
Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity
Przemysław Sitarek
,
Tomasz Kowalczyk
,
Laurent Picot
,
Dorota Michalska-Hejduk
,
Michał Bijak
,
Adam Białas
,
Marzena Wielanek
,
Tomasz Śliwiński
,
Ewa Skała
Industrial Crops and Products, Elsevier, 2018, 122, pp.732 - 739. 〈10.1016/j.indcrop.2018.06.059〉
Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib
Camille Juin
,
Raimundo Gonçalves de Oliveira Junior
,
Audrey Fleury
,
Chloé Oudinet
,
Lior Pytowski
,
Jean-Baptiste Bérard
,
Elodie Nicolau
,
Valérie Thiéry
,
Isabelle Lanneluc
,
Laureen Beaugeard
,
Grégoire Prunier
,
Jackson Roberto Guedes da Silva Almeida
,
Laurent Picot
Revista Brasileira de Farmacognosia, Elsevier, 2018, 28 (4), pp.457-467. 〈10.1016/j.bjp.2018.05.009〉
Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms
Raimundo Gonçalves De Oliveira Júnior
,
Christiane Adrielly Alves Ferraz
,
Jackson Roberto Guedes Da Silva Almeida
,
Raphäel Grougnet
,
Valérie Thiéry
,
Laurent Picot
Fitoterapia, Elsevier, In press, 〈10.1016/j.fitote.2018.02.025〉
Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome
Raimundo Gonçalves de Oliveira-Júnior
,
Christiane Alvez Ferraz
,
Michelle Pontes
,
Noelly Bastos Cavalcante
,
Edigênia Cavalcante da Cruz Araújoa
,
Ana Paula de Oliveira
,
Laurent Picot
,
Larissa Rolim
,
Jackson Guedes da Silva Almeida
European Journal of Integrative Medicine, In press
Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.
Alexandra Carvalho
,
Luana Heimfarth
,
Klécia Anjos
,
Adriana Gibara
,
Laurent Picot
,
Jackson Roberto Guedes da Silva Almeida
,
Jullyana De Souza Siqueira Quintans
,
Lucindo José Quintans Junior
Phytomedicine, Elsevier, In press
2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities
Nahida Mokhtari Brikci-Nigassa
,
Ghenia Bentabed-Ababsa
,
William Erb
,
Floris Chevallier
,
Laurent Picot
,
Lucille Vitek
,
Audrey Fleury
,
Valérie Thiéry
,
Mohamed Souab
,
Thomas Robert
,
Sandrine Ruchaud
,
Stéphane Bach
,
Thierry Roisnel
,
Florence Mongin
Tetrahedron, Elsevier, 2018, 74 (15), pp.1785-1801. 〈10.1016/j.tet.2018.02.038〉
2017
Article dans une revue
Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review
Raimundo Gonçalves Oliveira
,
Christiane Adrielly Alves Ferraz
,
Ana Paula Oliveira
,
Camila Souza Araújo
,
Layanne Feitosa da Silva Oliveira
,
Laurent Picot
,
Larissa Araújo Rolim
,
Pedro José Rolim-Neto
,
Jackson Roberto Guedes da Silva Almeida
Phytomedicine, Elsevier, 2017, 〈10.1016/j.phymed.2017.08.017〉
Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups
Benoît Serive
,
Elodie Nicolau
,
Jean-Baptiste Bérard
,
Raymond Kaas
,
Virginie Pasquet
,
Laurent Picot
,
Jean-Paul Cadoret
,
Adrianna Ianora
PLoS ONE, Public Library of Science, 2017, 12 (2), 〈10.1371/journal.pone.0171872〉
Antimelanoma activity of Heterocapsa triquetra pigments
Quentin Haguet
,
Antoine Bonnet
,
Jean-Baptiste Bérard
,
Joelle Goldberg
,
Nicolas Joguet
,
Audrey Fleury
,
Valérie Thiéry
,
Laurent Picot
Algal Research - Biomass, Biofuels and Bioproducts, Elsevier, 2017, 25, pp.207 - 215. 〈10.1016/j.algal.2017.04.034〉
Chapitre d'ouvrage
Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review
Renan Brito Guedes
,
P. Laise Santos
,
M. Almeida Oliveira
,
Lícia Tairiny Santos Pina
,
Angelo Roberto Antoniolli
,
Jackson Roberto Guedes da Silva Almeida
,
Gokhan Zengin
,
Laurent Picot
,
Jullyana De Souza Siqueira Quintans
,
Lucindo José Quintans Junior
Fibromyalgia and Peripheral Neuropathy , 2017
Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN
Raimundo Gonçalves de Oliveira Junior
,
Christiane Adrielly Alves Ferraz
,
Mariana Gama E Silva
,
Erica Martins de Lavor
,
Larissa Araújo Rolim
,
Julianeli Tolentino de Lima
,
Audrey Fleury
,
Laurent Picot
,
Jullyana De Souza Siqueira Quintans
,
Lucindo José Quintans Junior
,
Jackson Roberto Guedes da Silva Almeida
Natural Products and Cancer Drug Discovery , 2017
2016
Article dans une revue
Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?
Raimundo Gonçalves Oliveira-Junior
,
Valérie Thiéry
,
Odile Sergent
,
Martine Chevanne
,
Laurent Picot
Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. 〈10.4172/jomr.1000144 〉
2015
Article dans une revue
Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines
Nada Marquise
,
Tan Tai Nguyen
,
Floris Chevallier
,
Laurent Picot
,
Valérie Thiéry
,
Olivier Lozach
,
Stéphane Bach
,
Sandrine Ruchaud
,
Florence Mongin
SYNLETT, Georg Thieme Verlag, 2015, 26, pp.2811-2816. 〈10.1055/s-0035-1560496〉
Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship
Mohamed Yacine Ameur Messaoud
,
Ghenia Bentabed-Ababsa
,
Madani Hedidi
,
Aïcha Derdour
,
Floris Chevallier
,
Yury S. Halauko
,
Oleg A. Ivashkevich
,
Vadim E. Matulis
,
Laurent Picot
,
Valérie Thiéry
,
Thierry Roisnel
,
Vincent Dorcet
,
Florence Mongin
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.1475-1485. 〈10.3762/bjoc.11.160〉
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin
,
Antoine Bonnet
,
Elodie Nicolau
,
Jean-Baptiste Bérard
,
Devillers, Romain
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.2541-2558. 〈10.3390/md13042541〉
Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.
Camille Juin
,
Jean-René Chérouvrier
,
Valérie Thiery
,
Anne-Laure Gagez
,
Jean-Baptiste Bérard
,
Nicolas, Joguet
,
Raymond Kaas
,
Jean-Paul Cadoret
,
Laurent Picot
Biotechnology and Applied Biochemistry, Wiley, 2015, 〈10.1007/s12010-014-1250-2〉
UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum
Camille Juin
,
Antoine Bonnet
,
Elodie Nicolau
,
Jean-Baptiste Bérard
,
Devillers, Romain
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2015, 13 (4), pp.1541-2558. 〈10.3390/md13042541〉
2014
Article dans une revue
Lutter contre les cancers grâce aux pigments de microalgues
Laurent Picot
Biofutur, Elsevier - Cachan : Lavoisier, 2014
Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells
Madani Hedidi
,
Ghenia Bentabed-Ababsa
,
Aicha Derdour
,
Thierry Roisnel
,
Vincent Dorcet
,
Floris Chevallier
,
Laurent Picot
,
Valérie Thiery
,
Mongin Florence
Bioorg. Med. Chem., 2014, pp.1. 〈10.1016/j.bmc.2014.04.028〉
2013
Article dans une revue
Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation
Nada Marquise
,
Philip Harford
,
Floris Chevallier
,
Thierry Roisnel
,
Vincent Dorcet
,
Anne-Laure Gagez
,
Sophie Sablé
,
Laurent Picot
,
Valérie Thiéry
,
Andrew Wheatley
,
Philippe Gros
,
Florence Mongin
Tetrahedron, Elsevier, 2013, 69 (47), pp.10123-10133. 〈10.1016/j.tet.2013.09.030〉
Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
Paul-Hubert Baudelet
,
Anne-Laure Gagez
,
Jean-Baptiste Bérard
,
Camille Juin
,
Nicolas Bridiau
,
Raymond Kaas
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406
Towards the Clinical Use of Phytoplankton Carotenoid Pigments to Cure Cancer
Camille Juin
,
Valérie Thiéry
,
Jean-Paul Cadoret
,
Laurent Picot
oceanography, open access, 2013, 1 (3), 〈10.4172/2332-2632.1000e105〉
2012
Article dans une revue
The potential of microalgae for the production of bioactive molecules of pharmaceutical interest.
Virginie Mimouni
,
Lionel Ulmann
,
Virginie Pasquet
,
Marie Mathieu
,
Laurent Picot
,
Gaël Bougaran
,
Jean-Paul Cadoret
,
Annick Morant-Manceau
,
Benoît Schoefs
2012, 13 (15), pp.2733-2750
2011
Article dans une revue
Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts
Virginie Pasquet
,
Perrine Morisset
,
Saïd Ihammouine
,
Amandine Chepied
,
Lucie Aumailley
,
Jean-Baptiste Bérard
,
Benoît Serive
,
Raymond Kaas
,
Isabelle Lanneluc
,
Valérie Thiéry
,
Mathieu Lafferière
,
Jean-Marie Piot
,
Thierry Patrice
,
Jean-Paul Cadoret
,
Laurent Picot
Marine drugs, MDPI, 2011, 9, pp.819-831. 〈10.3390/md9050819〉
2010
Article dans une revue
Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties
Laurent Picot
,
Rozenn Ravallec
,
Martine Fouchereau-Peron
,
Laurent Vandanjon
,
Pascal Jaouen
,
Maryse Chaplain-Derouiniot
,
Fabienne Guérard
,
Aurelie Chabeaud
,
Yves Legal
,
Oscar Martinez Alvarez
,
Jean-Pascal Bergé
,
Jean-Marie Piot
,
Irineu Batista
,
Carla Pires
,
Gudjon Thorkelsson
,
Charles Delannoy
,
Greta Jakobsen
,
Inez Johansson
,
Patrick Bourseau
Journal of the Science of Food and Agriculture, Wiley, 2010, 90 (11), pp.1819-1826. 〈10.1002/jsfa.4020〉
2009
Article dans une revue
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives
Anne Beauchard
,
Alexis Jaunet
,
Laurence Murillo
,
Brigitte Baldeyrou
,
Amélie Lansiaux
,
Jean-René Chérouvrier
,
Lisianne Domon
,
Laurent Picot
,
Christian Bailly
,
Thierry Besson
European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (10), pp.3858 - 3865. 〈10.1016/j.ejmech.2009.04.012〉
2005
Article dans une revue
Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.
Alexandra Testard
,
Laurent Picot
,
Olivier Lozach
,
Melina Blairvacq
,
Laurent Meijer
,
Laurence Murillo
,
Jean-Marie Piot
,
Valérie Thiéry
,
Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-68