Picot Laurent, MCF-HDR

Équipe de rattachement : BCBS
Statut : Chercheur
laurent.picot@univ-lr.fr
Tél. : +33 (0)5 46 45 82 20

Enseignant-chercheur, Maître de Conférences
Université de La Rochelle
Section de Recherche : CNU 64
Institut scientifique du CNRS référent : INEE

Mots clés : Anticancéreux, microalgues marines, pigments, hétérocycles, pharmacologie

Animateur des thématiques de recherche "Pigments marins et Photothérapie dynamique des tumeurs" et "Composition et activité pharmacologique de plantes terrestres Brésiliennes"

Responsable pour l’université de La Rochelle du Projet Européen Interreg Enhance Microalgae

Editeur invité numéro spécial "Antiproliferative Marine Natural products" de la revue "Marine Drugs"

Thèmes de Recherche.

Recherche d’anticancéreux dans l’environnement marin, pharmacologie des anticancéreux
Extraction, purification, caractérisation moléculaire, activité pharmacologique de pigments de microalgues marines et de plantes terrestres
Valorisation biotechnologique des ressources marines et botaniques en cancérologie
Anticancéreux hétérocycliques

Liste des publications :

49 résultats

2020

Article dans une revue

Analysis of Scientific Research Driving Microalgae Market Opportunities in Europe

Judith Rumin , Elodie Nicolau , Raimundo Gonçalves de Oliveira Junior , Claudio Fuentes-Grünewald , Laurent Picot

Marine drugs, MDPI, 2020, 18 (5), pp.264. ⟨10.3390/md18050264⟩

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A Bibliometric Analysis of Microalgae Research in the World, Europe, and the European Atlantic Area

Judith Rumin , Elodie Nicolau , Raimundo Gonçalves de Oliveira Junior , Claudio Fuentes-Grünewald , Kevin Flynn , Laurent Picot

Marine drugs, MDPI, 2020, 18 (2), pp.79. ⟨10.3390/md18020079⟩

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Thermophysiologies of Jurassic marine crocodylomorphs inferred from the oxygen isotope composition of their tooth apatite

Nicolas Séon , Romain Amiot , Jeremy Martin , Mark Young , Heather Middleton , François Fourel , Laurent Picot , Xavier Valentin , Christophe Lécuyer

Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2020, 375 (1793), ⟨10.1098/rstb.2019.0139⟩

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Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest

Blandine Baratte , Nahida Mokhtari Brikci-Nigassa , Lionel Nauton , Pascale Moreau , Olivier Mongin , Raphael Duval , Laurent Picot , Valérie Thiery , Mohamed Souab , Sandrine Ruchaud , Stéphane Bach , Rémy Le Guével , Ghenia Bentabed-Ababsa , William Erb , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Bioorganic Chemistry, Elsevier, 2020, 94, pp.103347. ⟨10.1016/j.bioorg.2019.103347⟩

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2019

Article dans une revue

Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review

Christiane Adrielly Alves Ferraz , Raimundo Gonçalves de Oliveira Júnior , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Xirley Pereira Nunes

Fitoterapia, Elsevier, 2019, 137, pp.104196. ⟨10.1016/j.fitote.2019.104196⟩

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From ecological relevance of the ecosystem services concept to its socio-political use. The case study of intertidal bare mudflats in the Marennes-Oléron Bay, France

Benoit Lebreton , Audrey Rivaud , Laurent Picot , Benoît Prévost , Laurent Barillé , Thierry Sauzeau , Jennifer Beseres Pollack , Johann Lavaud

Ocean and Coastal Management, Elsevier, 2019, 172, pp.41-54. ⟨10.1016/j.ocecoaman.2019.01.024⟩

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An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity

Ewa Skała , Laurent Picot , Michał Bijak , Joanna Bijak , Janusz Szemraj , Agnieszka Kicel , Monika Olszewska , Przemysław Sitarek

Industrial Crops and Products, Elsevier, 2019, 129, pp.327-338

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Chemical constituents of non-polar fractions obtained from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant native to Caatinga biome Chemical constituents of non-polar fractions obtained from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant native to Caatinga biome

Raimundo G. de Oliveira-Júnior , Christiane Adrielly A. Ferraz , Ana Paula de Oliveira , José Marcos T. de Alencar-Filho , Edigênia C. C. Araújo , Xirley P. Nunes , Laurent Picot , Norberto Lopes , Raimundo Braz-Filho , Larissa A. Rolim , Jackson Roberto G. da S. Almeida

Revista Virtual de Química, 2019, 11 (2), pp.498-516. ⟨10.21577/1984-6835.20190038⟩

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Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity

Raimundo Gonçalves de Oliveira Júnior , Antoine Bonnet , Estelle Braconnier , Hugo Groult , Grégoire Prunier , Laureen Beaugeard , Raphäel Grougnet , Jackson Roberto Guedes da Silva Almeida , Christiane Adrielly Alves Ferraz , Laurent Picot

Food and Chemical Toxicology, Elsevier, 2019, 125, pp.549-561. ⟨10.1016/j.fct.2019.02.013⟩

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Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review

Priscila Santos , João Pedro S.C.F. Matos , Laurent Picot , Jackson R.G.S. Almeida , Jullyana S.S. Quintans , Lucindo J. Quintans-Junior

Food and Chemical Toxicology, Elsevier, 2019, 123, pp.459-469. ⟨10.1016/j.fct.2018.11.030⟩

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Monoterpenes modulating cytokines - A review

Jullyana S.S. Quintans , Saravanan Shanmugam , Luana Heimfarth , Adriano Antunes S. Araújo , Jackson R.G.da S. Almeida , Laurent Picot , Lucindo Quintans-Júnior

Food and Chemical Toxicology, Elsevier, 2019, 123, pp.233-257

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Crystal Structure of 6,7-Dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-dione

Jean Guillon , Maria de Fatima Pereira-Rosenfeld , Noël Pinaud , Thierry Besson , Valérie Thiéry , Laurent Picot , Mathieu Marchivie

X-Ray Structure Analysis Online, Japan Society for Analytical Chemistry's, 2019, 35 (10), pp.57-59. ⟨10.2116/xraystruct.35.57⟩

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2018

Article dans une revue

Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity

Przemysław Sitarek , Tomasz Kowalczyk , Laurent Picot , Dorota Michalska-Hejduk , Michał Bijak , Adam Białas , Marzena Wielanek , Tomasz Śliwiński , Ewa Skała

Industrial Crops and Products, Elsevier, 2018, 122, pp.732 - 739. ⟨10.1016/j.indcrop.2018.06.059⟩

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Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome

Raimundo Gonçalves de Oliveira-Júnior , Christiane Alvez Ferraz , Michelle Pontes , Noelly Bastos Cavalcante , Edigênia Cavalcante da Cruz Araújoa , Ana Paula de Oliveira , Laurent Picot , Larissa Rolim , Jackson Guedes da Silva Almeida

European Journal of Integrative Medicine, In press

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EnhanceMicroalgae: An European Interregional Project Stimulating Research, Innovation, Industrial Development and Transnational Cooperation within the Atlantic Area Microalgae Sector

Judith Rumin , Joana Martins , Jose Cruz , Vitor Vasconcelos , Claudio Fuentes Grünewald , Kevin J. Flynn , Alejandra Sabin , Maria Paredes , Enma Conde , Jose Vilarino , Martina Ferreira , Federica Farabegoli , Paula Fajardo , Maria-José Chapela , Laurent Picot

Journal of Oceanography and Marine Research, 2018, 6 (3), pp.1000182. ⟨10.4172/2572-3103.1000182⟩

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From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin , Manon Boullard , Coline Courtel , Idriss Curbet , Clément Gédéon , Julien Lebreton , Laurent Picot , Valérie Thiéry , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin

Molecules, MDPI, 2018, 23 (11), pp.2961. ⟨10.3390/molecules23112961⟩

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Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review.

Alexandra Carvalho , Luana Heimfarth , Klécia Anjos , Adriana Gibara , Laurent Picot , Jackson Roberto Guedes da Silva Almeida , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior

Phytomedicine, Elsevier, In press, ⟨10.1016/j.phymed.2018.10.028⟩

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2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot , Lucille Vitek , Audrey Fleury , Valérie Thiéry , Mohamed Souab , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Thierry Roisnel , Florence Mongin

Tetrahedron, Elsevier, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩

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Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms

Raimundo Gonçalves de Oliveira Júnior , Christiane Adrielly Alves Ferraz , Jackson Roberto Guedes da Silva Almeida , Raphäel Grougnet , Valérie Thiéry , Laurent Picot

Fitoterapia, Elsevier, In press, ⟨10.1016/j.fitote.2018.02.025⟩

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Zeaxanthin from Porphyridium purpureum induces apoptosis in human melanoma cells expressing the oncogenic BRAF V600E mutation and sensitizes them to the BRAF inhibitor vemurafenib

Camille Juin , Raimundo Gonçalves de Oliveira Junior , Audrey Fleury , Chloé Oudinet , Lior Pytowski , Jean-Baptiste Bérard , Elodie Nicolau , Valérie Thiéry , Isabelle Lanneluc , Laureen Beaugeard , Grégoire Prunier , Jackson Roberto Guedes da Silva Almeida , Laurent Picot

Revista Brasileira de Farmacognosia, Elsevier, 2018, 28 (4), pp.457-467. ⟨10.1016/j.bjp.2018.05.009⟩

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Communication dans un congrès

Natural compounds targeting pyocyanin and quorum sensing in Pseudomonas aeruginosa

Ali Tahrioui , Onyedikachi Azuama , Sergio Ortiz , Raimundo Gonçalves , Damien Tortuel , Olivier Maillot , Chouaha Bouzidi , Laurent Picot , Raphaël Grougnet , Sabrina Boutefnouchet , Marina Kritsanida , Marc Feuilloley , Nicole Orange , Sylvie Michel , Olivier Lesouhaitier , Emeline Bouffartigues , Sylvie Chevalier

Congrès National de la Société Française de Microbiologie-SFM2018, Oct 2018, Paris, France

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2017

Article dans une revue

Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: a systematic review

Raimundo Gonçalves Oliveira , Christiane Adrielly Alves Ferraz , Ana Paula Oliveira , Camila Souza Araújo , Layanne Feitosa da Silva Oliveira , Laurent Picot , Larissa Araújo Rolim , Pedro José Rolim-Neto , Jackson Roberto Guedes da Silva Almeida

Phytomedicine, Elsevier, 2017, ⟨10.1016/j.phymed.2017.08.017⟩

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Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups

Benoît Serive , Elodie Nicolau , Jean-Baptiste Bérard , Raymond Kaas , Virginie Pasquet , Laurent Picot , Jean-Paul Cadoret , Adrianna Ianora

PLoS ONE, Public Library of Science, 2017, 12 (2), ⟨10.1371/journal.pone.0171872⟩

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Antimelanoma activity of Heterocapsa triquetra pigments

Quentin Haguet , Antoine Bonnet , Jean-Baptiste Bérard , Joelle Goldberg , Nicolas Joguet , Audrey Fleury , Valérie Thiéry , Laurent Picot

Algal Research - Biomass, Biofuels and Bioproducts, Elsevier, 2017, 25, pp.207 - 215. ⟨10.1016/j.algal.2017.04.034⟩

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Chapitre d'ouvrage

Natural products as promising pharmacological tools for the management of fibromyalgia symptoms – a review

Renan Brito Guedes , P. Laise Santos , M. Almeida Oliveira , Lícia Tairiny Santos Pina , Angelo Roberto Antoniolli , Jackson Roberto Guedes da Silva Almeida , Gokhan Zengin , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior

Fibromyalgia and Peripheral Neuropathy , 2017

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Chapter 8 : Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma). in Natural Products and Cancer Drug Discovery Edited by Farid A. Badria, ISBN

Raimundo Gonçalves de Oliveira Junior , Christiane Adrielly Alves Ferraz , Mariana Gama E Silva , Erica Martins de Lavor , Larissa Araújo Rolim , Julianeli Tolentino de Lima , Audrey Fleury , Laurent Picot , Jullyana de Souza Siqueira Quintans , Lucindo José Quintans Junior , Jackson Roberto Guedes da Silva Almeida

Natural Products and Cancer Drug Discovery , 2017

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2016

Article dans une revue

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

Raimundo Gonçalves Oliveira-Junior , Valérie Thiéry , Odile Sergent , Martine Chevanne , Laurent Picot

Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. ⟨10.4172/jomr.1000144⟩

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2015

Article dans une revue

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines

Nada Marquise , Tan Tai Nguyen , Floris Chevallier , Laurent Picot , Valérie Thiéry , Olivier Lozach , Stéphane Bach , Sandrine Ruchaud , Florence Mongin

SYNLETT, Georg Thieme Verlag, 2015, 26 (20), pp.2811-2816. ⟨10.1055/s-0035-1560496⟩

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Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship

Mohamed Yacine Ameur Messaoud , Ghenia Bentabed-Ababsa , Madani Hedidi , Aïcha Derdour , Floris Chevallier , Yury S. Halauko , Oleg A. Ivashkevich , Vadim E. Matulis , Laurent Picot , Valérie Thiéry , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.1475-1485. ⟨10.3762/bjoc.11.160⟩

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Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum.

Camille Juin , Jean-René Chérouvrier , Valérie Thiery , Anne-Laure Gagez , Jean-Baptiste Bérard , Nicolas, Joguet , Raymond Kaas , Jean-Paul Cadoret , Laurent Picot

Biotechnology and Applied Biochemistry, Wiley, 2015, ⟨10.1007/s12010-014-1250-2⟩

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UPLC-MSE Profiling of Phytoplankton Metabolites: Application to the Identification of Pigments and Structural Analysis of Metabolites in Porphyridium purpureum

Camille Juin , Antoine Bonnet , Elodie Nicolau , Jean-Baptiste Bérard , Devillers, Romain , Valérie Thiéry , Jean-Paul Cadoret , Laurent Picot

Marine drugs, MDPI, 2015, 13 (4), pp.1541-2558. ⟨10.3390/md13042541⟩

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2014

Article dans une revue

Lutter contre les cancers grâce aux pigments de microalgues

Laurent Picot

Biofutur, Elsevier - Cachan : Lavoisier, 2014

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Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

Madani Hedidi , Ghenia Bentabed-Ababsa , Aicha Derdour , Thierry Roisnel , Vincent Dorcet , Floris Chevallier , Laurent Picot , Valérie Thiery , Mongin Florence

Bioorganic and Medicinal Chemistry, Elsevier, 2014, 22 (13), pp.3498-3507. ⟨10.1016/j.bmc.2014.04.028⟩

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2013

Article dans une revue

Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation

Nada Marquise , Philip Harford , Floris Chevallier , Thierry Roisnel , Vincent Dorcet , Anne-Laure Gagez , Sophie Sablé , Laurent Picot , Valérie Thiéry , Andrew Wheatley , Philippe Gros , Florence Mongin

Tetrahedron, Elsevier, 2013, 69 (47), pp.10123-10133. ⟨10.1016/j.tet.2013.09.030⟩

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Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

Pseudomonas fluorescens as a potential pathogen: adherence to nerve cells

Laurent Picot , Sana Mezghani Abdelmoula , Annabelle Mérieau , Philippe Leroux , Lionel Cazin , Nicole Orange , Marc G.J Feuilloley

Microbes and Infection, Elsevier, 2001, 3 (12), pp.985-995. ⟨10.1016/s1286-4579(01)01462-9⟩

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