Rosenfeld Eric

Associate Professor
University of La Rochelle - UMR CNRS 7266 LIENSs - France

Keywords : Microbial physiology, iridescence, Cellulophaga lytica, cell-to-cell communication, Pseudomonas aeruginosa, pyocyanin, redox, respiration.

Research topics
1/ Bacterial iridescence. Iridescence of a marine bacterium (Cellulophaga lytica). Modeling and microbiological studies (multiple approaches)..
Main partnerships: Tâm Mignot (LCB, CNRS Marseille), Dimitri Deheyn (Scripps Institution of Oceanography, UC San Diego, USA), Renaud Péteri (MIA, La Rochelle), Eric Duchaud (INRA Jouy en Josas), Peter Vukusic (School of physics, Exeter, UK), Fabien Joux, LOMIC UMR 7621 CNRS-UPMC Banyuls sur mer.
Iridescence of the marine bacterium Cellulophaga lytica

2/ Physiological and redox properties of pyocyanin, a pigment produced by Pseudomonas aeruginosa.
Recent partnerships: Stephen Manon (CNRS Bordeaux), Dianne Newman (CalTech, USA). Partnership with Christine Baysse (Rennes 1): respiration and oxidative stress in gram-negative bacteria.

Physiological properties of the redox-active blue pigment, pyocyanin (e.g. anaerobic yeast cells as target organism)

Recent supervisons of research projects as Principal Investigator (PI) (2010-2017):
- 2 projects funded by the National Center of Scientific Research [“MODIRIS in mobile” (2014-2016, 35k€) and “Bacteridescence” (2011, 31 k€)]
- 1 ERC Consolidator Grant project refused at step 2 (2014-2015, “Bacteroidescence”).
- 1 project (in progress, 2016-2017) funded by the European Marine Biological Resource Centre (EMBRC) (5 k€ and research missions in partnership with F. Joux, LOMIC, CNRS Banyuls/mer, France)
- Projects funded by the French association « Vaincre la mucoviscidose » (2008 to 2010, 155k€, Research of new bacterial molecules targeting Pseudomonas aeruginosa).
- 3 research grants (“ACI” “Incentive actions”) at ULR, France
PhD Supervisions:
- 2014-2017 Supervisor of the PhD thesis of Maylis Chapelais-Baron. Co-supervisor: Dr Isabelle Goubet (ULR). Sujet : « L’iridescence remarquable de la bactérie marine Cellulophaga lytica : étude des mécanismes impliqués dans la formation des structures multicellulaires iridescente s ». Close partnership with Tâm Mignot (LCB Marseille) for the genetic study.
- 2009-2012 Supervisor of the PhD thesis of Betty Kientz. Sujet : « Etude de l’iridescence d’une bactérie marine, Cellulophaga lytica : caractérisations physico-optique, microbiologique et écologique. »
- 2010-2012 Supervisor of the PhD thesis of Rana Barakat. Co-supervisor : Dr Isabelle Goubet. Sujet : « Etude des propriétés biologiques et antimicrobiennes de la pyocyanine, pigment redox-actif produit par Pseudomonas aeruginosa »

Publications :
Main thematic (Bacterial iridescence)
• Chapelais-Baron M, Goubet I, Duchaud E, Rosenfeld E (2017). Draft Genome sequence of the iridescent marine bacterium Cellulophaga lytica CECT 8139. Gen Announc (in press).
• Kientz B, Luke S, Vukusic P, Péteri R, Beaudry C, Renault T, Simon D, Mignot T, Rosenfeld E. A unique self-organization of bacterial sub-communities creates iridescence in Cellulophaga lytica colony biofilms. Sci Rep. 6:19906. doi:10.1038/srep19906.
• Kientz B, Agogué H, Lavergne C, Marié P, Rosenfeld E. (2013) Isolation and distribution of iridescent Cellulophaga and other iridescent marine bacteria from the Charente-Maritime coast, French Atlantic. Syst Appl Microbiol. 36(4):244-51
• Kientz B, Ducret A, Luke S, Vukusic P, Mignot T, Rosenfeld E. (2012) Glitter-like iridescence within the Bacteroidetes especially Cellulophaga spp.: optical properties and correlation with gliding motility. PLoS One. 7(12):e52900. doi: 10.1371/journal.pone.0052900.
• Kientz B, Vukusic P, Luke S, Rosenfeld E. (2012) Iridescence of a marine bacterium and classification of prokaryotic structural colors. Appl Environ Microbiol. 78(7):2092-9
• Kientz B, Marié P, Rosenfeld E. (2012) Effect of abiotic factors on the unique glitter-like iridescence of Cellulophaga lytica. FEMS Microbiol Lett. 333(2):101-8.

Other recent publications
• Leclerc J, Rosenfeld E, Trainini M, Martin B, Meuric B, Bonnaure-Mallet M, Baysse C. (2015) The cytochrome bd oxidase of Porphyromonas gingivalis contributes to oxidative stress resistance and dioxygen tolerance. PLoS One. 10(12):e0143808. doi: 10.1371/journal.pone.0143808
• Barakat, R., Goubet, I., Manon, S., Berges, T. and Rosenfeld, E. (2014), Unsuspected pyocyanin effect in yeast under anaerobiosis. MicrobiologyOpen. doi: 10.1002/mbo3.142
• Dufour V, Stahl M, Rosenfeld E, Stintzi A, Baysse C. (2013) Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni. Appl Environ Microbiol. 79(22):6958-68
• Dufour V, Li J, Flint A, Rosenfeld E, Rivoal K, Georgeault S, Alazzam B, Ermel G, Stintzi A, Bonnaure-Mallet M, Baysse C. (2013). Inactivation of the LysR regulator Cj1000 of Campylobacter jejuni affects host colonization and respiration. Microbiology. 159(6):1165-78.
• R. Chèvrot, S. Didelot, L. Van den Bossche, P. Marchand, E. Izquierdo, V.Sopena, J. Caillon, A. Van Schepdael, J. Hoogmartens, E. Rosenfeld (2013). A Novel Depsipeptide Produced by Paenibacillus alvei 32 Isolated from a Cystic fibrosis Patient. Probiotics & Antimicrob. Prot. DOI 10.1007/s12602-012-9121-z

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