Our team’s axis 2 is interested in developing and applying different methodologies aiming to improve biological effects of molecules produced in axis 1. Therefore, several strategies (functionalization, encapsulation, nanovectorization, actives combination) are studied.
Thematic 1: Potentiate anti-cancerous effects
Project 1: Modification of bioactive molecules by chemical/enzymatic functionalization
Synthesis of small polynitrogen heterocyclic of different types such as diazaindole, oxindoles polynitrogen, thiazolopiridazoindazoles, targeting kinases (CDK, PI3Kα, haspine, or DYRK1A/CLK1) involved in the RNAm’s splicing and carcinogenesis process. Valérie Thiery
Project 2: Conception of nano-objects for guided biotherapies of tumor microenvironment and diagnostic monitoring by clinic imaging
Key words: tumorous microenvironment, iron oxide nanoparticles, positive contrast MRI, vectorization, sulfated polysaccharides, heparanase inhibitors
Conception and characterization of a new generation of iron oxide nanoparticles (IONP) extremely tiny, bio-conjugated to sulfated polysaccharides able to produce a positive contrast in magnetic resonance imaging (MRI). Hugo Groult
Analysis in vivo of the bio-distribution of anti-tumorous nanovectors by MRI imaging among mice, and pharmacokinetics. Optimization towards bimodal diagnostic probes. (PET/MRI) Hugo Groult
Thematic 2: Potentiate cosmetic and nutraceutical effects
Project 1: Actives encapsulation / Formulation
Elaboration of encapsulation systems with monitored release of actives coming from natural biopolymers of marine or terrestrial plants sources. Jérémy Carpentier (PhD student)
Thematic 3: Potentiate anti-microbial effects
Project 1: Combined action of molecules, synergy and restauration of sensitivity to antibiotics of pathogenic bacteria.
Project 2: Synthesis and modification by chemical means, or by genetic engineering of molecules of interest