Axis 1 : discovery, identification and characterization of natural or bio-inspired bioactives molecules

In this axis, skills in extraction, biotechnologies, and synthesis chemistry under microwave, are applied to different biomasses (micro/macro algae and marine bacteria), biological polymers or secondary metabolites. This way, different families of natural molecules or analog synthesis are obtained (glycomolecules, heterocyclic compounds, peptides, pigments, polyphenols) with the purpose to have anti-cancerous, cardio-metabolic, anti-microbial, and dermo-cosmetic applications.

The different skills of the team enable us to evaluate the molecules for their different biological activities: anti-proliferative, cytotoxic, regulators of tumorous progress’s process (invasion, migration, angiogenesis), anti-microbial, anti-oxidant, anti-inflammatory… (on cellular lines or molecular targets).

These projects are also accompanied by the development of technological methods for the purification and the characterization (mass spectrometry-chromatography) of biological actives.

Thematic 1: Novel natural compounds with anti-cancer potential


Project 1: Natural pigments and alkaloid in oncology

Key words: marine micro-algae, pigments, pharmacology, cell signaling, kinase inhibitors

- Extraction, purification, characterization of biological activity of original molecules on a model of metastatic human melanoma and chemo-resistant, pharmacology of carotenoid pigments. Laurent Picot

- Molecular and cellular mechanisms occurring during cytotoxic effects of carotenoid pigments from micro algae. Audrey Fleury

- Identification of cytostatic molecules able to sensitize cancerous cells in order to potentiate treatments and decrease the resistance mechanisms toward anti-tumorous treatment. Raimundo Goncalves de Oliveira junior (PhD student)

- European project Interreg Enhance Microalgae: development of a database and an in-depth analysis of microalgae industrial promotion opportunities in the European Atlantic arc. Judith Rumin

- Conception and synthesis of new pharmacologic inhibitors of key kinases in carcinogenesis. Original synthesis of new indigoid’s analogs. (diazaindoles, 3rd indolin-substitution-2-one). Valérie Thiery, Lisianne Domon, Jean-René Cherouvrier.

Project 2: Natural oligosaccharides in oncology

Key words: Cancer, tumorous microenvironment, neo-vascularization, sulfated oligosaccharides of natural origin, heparanase

- Polysaccharides’ synthesis, structural mimes of sulfate heparan, inhibitors of heparanase, a glycoside hydrolase involved in pro-tumorous angiogenesis. Thierry Maugard, Hugo Groult (post-doctoral)

- Evaluation of in vitro biologic activity based on cellular models and in vivo based on mouse tumor models. This project is subject to a PhD, a post-doctoral and activities from researchers. Ingrid Arnaudin, Jean-Marie Piot, Isabelle Lanneluc, Grazielo Geneau, Rémi Cousin (PhD student)

Thematic 2: Novel natural compounds with nutraceutical and dermo-cosmetics potential

Key words: marine polysaccharides, marine peptides, metabolic syndrome, inflammation, insulin-resistance

- Valorization of macro-algae fractions obtained by the Seprosys method as active agents usable in the dermo-cosmetic and nutraceutical fields. This project is subject to a PhD and activities from researchers: Thierry Maugard,Nicolas Bridiau, Justine Bodin (PhD student)

- Sifting of marine peptides that can regulate some metabolic parameters associated with type 2 diabetes, dyslipidemia, arterial hypertension, and obesity. Stéphanie Bordenave

- Valorization of micro and macro-algae fragments for the development of actives targeting inflammation, and alteration mechanisms of the emotional behavior bound to metabolic disorders. Projet Neuronalg

- Valorization of exopolysaccharides from micro-algae for dermo-cosmetic and nutraceutical applications. This project is subject to a PhD and activities from researchers: Thierry Maugard, Nicolas Bridiau, Ingrid Arnaudin, Claire Toucheteau

Thematic 3: Novel natural compounds with anti-microbial potential

Key words: antibiofilm, metagenomics, non-ribosomal peptides, antibiotics

- Sifting of microbial stain of interest, producing inhibitors causing virulence (for instance antibiofilm) and/or growing. Isabelle Lanneluc, Sophie Sablé

- Identification of anti-microbial molecules, by the use of competitive phenomenons between microorganisms. Romain Chevrot, Sandrine Didelot, Cyrille Barthelemy

- Analysis of metagenomics banks and high-speed sequencing for the bioproduction of antibiotic non-ribosomal peptides. Conception and synthesis of innovative non-ribosomal peptides. Romain Chevrot, Cyrille Barthelemy, Caroline Salsano (PhD student)

- Sifting and identification of probiotic stems able to produce growth inhibitors. Sophie Sablé, Romain Chevrot, Sandrine Didelot, Sabrina Saltaji (PhD student).

publie le Thursday 14 June 2018